Escitalopram for Autism
Trial Summary
What is the purpose of this trial?
The goal of this clinical trial is to evaluate the acute effects of escitalopram (Lexapro®) on select brain networks during task-based functional magnetic resonance imaging (fMRI) in adolescent individuals with autism spectrum disorder (ASD). We hope to learn more about the acute effects of escitalopram and how it might be used to treat inflexible thinking or rigid-compulsive behavior that can be associated with restricted and repetitive behaviors in adolescents with ASD. Participants will: * Attend 3 visits to complete tests of thinking abilities and fill out surveys about their health and behavior * Be randomly assigned to receive escitalopram at one of the first two visits after screening and a placebo at the other visit. * Complete 2 MRI scans while doing a reward-based task that tracks eye movement
Do I have to stop taking my current medications for the trial?
The trial requires participants to continue their current medications and not make any changes to them during the study.
Is escitalopram generally safe for humans?
Escitalopram has been studied for safety in various conditions like depression and anxiety, showing it is generally well-tolerated in both adults and adolescents. Some studies report it as safe when used alone or with other treatments, with common side effects being mild and including nausea and headache.12345
How does the drug escitalopram differ from other treatments for autism?
Escitalopram is unique because it is a selective serotonin reuptake inhibitor (SSRI) primarily used to treat depression and anxiety, and its use for autism is novel as there are no standard treatments specifically approved for autism. Its mechanism of action involves increasing serotonin levels in the brain, which may help with mood and anxiety symptoms that can be present in autism.56789
Research Team
Kathryn E Unruh, PhD
Principal Investigator
University of Kansas
Eligibility Criteria
This trial is for adolescents with Autism Spectrum Disorder who can undergo MRI scans and complete cognitive tests. They should not have any health conditions that interfere with the study or be taking medications that affect brain function.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a single dose of escitalopram or placebo and undergo fMRI scans
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Escitalopram
Find a Clinic Near You
Who Is Running the Clinical Trial?
Kathryn Unruh
Lead Sponsor