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Memantine and Behavioral Therapy for Skin Picking Disorder

Phase 2 & 3

Recruiting

Led By Jon E Grant, MD, JD, MPH

Research Sponsored by University of Chicago

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Current DSM-5 diagnosis of trichotillomania (TTM) or skin picking disorder (SPD)

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 20 weeks

Awards & highlights

Study Summary

"This trial aims to compare the effectiveness of behavioral treatment to memantine, a medication, for individuals with trichotillomania or skin picking disorder. Participants will undergo 8 weeks of memantine

Who is the study for?

This trial is for adults 18+ with Trichotillomania or Skin Picking Disorder who can consent to participate. They must have a stable medication dose for the past 3 months and meet certain diagnostic criteria.Check my eligibility

What is being tested?

The study compares behavioral therapy (ComB) with Memantine, a drug, in treating Body Focused Repetitive Behaviors over 16 weeks. It tests if ComB leads to better outcomes than Memantine or if both show improvements.See study design

What are the potential side effects?

Memantine may cause dizziness, headache, confusion, constipation, or high blood pressure. Behavioral therapy typically does not have physical side effects but can sometimes cause emotional discomfort.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have been diagnosed with a disorder that makes me pull out my hair or pick my skin.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 20 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~20 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 20 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

National Institutes of Mental Health Symptom Severity Scale (for trichotillomania or Skin Picking) (NIMH-TSS or NIMH-SPS)

Secondary outcome measures

Barratt Impulsiveness Scale (BIS)

Clinical Global Impressions -- Improvement Scale (CGI-I)

Hamilton Anxiety Rating Scale (HAM-A)

+5 more

Trial Design

1Treatment groups

Experimental Treatment

Group I: Memantine and Behavioral TherapyExperimental Treatment2 Interventions

All subjects will receive 8-weeks of memantine treatment (10mg po qday for the first two weeks, then 20 mg po qday for the remaining six weeks). After the 8-weeks of memantine treatment, the dose will be discontinued. Then, after a 4-week washout period, all subjects will receive 8-weeks of ComB therapy. Therapy will be once a week for 30 minutes. After the 8-weeks of ComB treatment, the therapy will be discontinued.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Memantine

2006

Completed Phase 4

~1200

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of ChicagoLead Sponsor

1,004 Previous Clinical Trials

819,749 Total Patients Enrolled

Jon E Grant, MD, JD, MPHPrincipal InvestigatorUniversity of Chicago

9 Previous Clinical Trials

453 Total Patients Enrolled

Gregory Chasson, PhDPrincipal InvestigatorUniversity of Chicago

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the current number of participants being recruited for this clinical study?

"Indeed, the information available on clinicaltrials.gov indicates that patient enrollment is ongoing for this trial. The trial was initially listed on 8th February 2023 and last modified on 2nd February 2024. Recruitment aims to enlist a total of 28 participants from one designated site."

Answered by AI

Is the process of enrolling participants currently underway for this clinical trial?

"As per clinicaltrials.gov, this research is actively seeking individuals to take part. The initial posting date was August 2nd, 2023, and the latest update was made on February 2nd, 2024."

Answered by AI

Who else is applying?

What site did they apply to?

University of Chicago Medical Center

What portion of applicants met pre-screening criteria?

Did not meet criteria

Met criteria

Why did patients apply to this trial?

I’ve tried everything to stop pulling out my hair and picking my skin. I need help.

PatientReceived no prior treatments

I suspected that I had trichotillomania since I was 13 years old and I was recently diagnosed after doing psychological testing. I want to improve my symptoms.

PatientReceived 1 prior treatment

I suspected that I had trichotillomania since I was 13; however, I was officially diagnosed until a few months ago. I would like to improve my symptoms overall.

PatientReceived 2+ prior treatments

I’ve tried multiple medications and a trichotillomania specialist therapist. I feel like I have accessed all of the tools to stop but I am not able to successfully complete the therapy portion.

PatientReceived 2+ prior treatments