Celecoxib + Chemotherapy for Bladder Cancer
(BLAST Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to compare patient tumor tissue before and after treatment with chemotherapy plus celecoxib. Investigators will look at gene expression, to see what effect celecoxib may have on tumor cells.
Will I have to stop taking my current medications?
The trial requires that you stop regular use of NSAIDs (non-steroidal anti-inflammatory drugs) more than twice a week and aspirin more than 325 mg at least three times a week. Low-dose aspirin up to 100 mg per day is allowed, and no washout period is needed if you stop the higher doses.
Is the combination of Celecoxib and chemotherapy safe for treating bladder cancer?
Cisplatin, a chemotherapy drug often used in bladder cancer treatment, can cause side effects like nausea, vomiting, and kidney problems. In some studies, severe blood-related side effects and kidney failure were noted, especially in patients with existing kidney issues. Gemcitabine, another chemotherapy drug, is generally considered safe but can also cause side effects like low blood counts and fatigue.12345
What makes the drug combination of Celecoxib, Cisplatin, and Gemcitabine unique for treating bladder cancer?
This drug combination is unique because it includes Celecoxib, a COX-2 inhibitor, which may enhance the effects of chemotherapy drugs like Cisplatin and Gemcitabine by inhibiting tumor growth and reducing recurrence, offering a novel approach compared to standard treatments that typically rely on direct chemotherapy or immunotherapy alone.678910
What data supports the effectiveness of the drug combination Celecoxib, Cisplatin, and Gemcitabine for bladder cancer?
Who Is on the Research Team?
Aihua Edward Yen, MD
Principal Investigator
Baylor College of Medicine
Are You a Good Fit for This Trial?
This trial is for adults with localized, muscle-invasive bladder cancer who haven't had systemic chemotherapy. They need recent scans and tests showing good organ function, no severe neuropathy or uncontrolled illnesses, not pregnant/nursing, and can't be regularly using NSAIDs or have a history of significant bleeding or heart issues.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive neoadjuvant chemotherapy with Celecoxib, Gemcitabine, and Cisplatin
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Celecoxib
- Cisplatin
- Gemcitabine
Cisplatin is already approved in European Union, United States, Canada, Japan for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
Baylor College of Medicine
Lead Sponsor