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Angiotensin II for High Blood Pressure

Phase 1
Waitlist Available
Led By Luminita Pojoga, PhD
Research Sponsored by Brigham and Women's Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
age 18-65
mild to moderate hypertension
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5 years
Awards & highlights

Study Summary

This trial is investigating why patients develop high blood pressure, atherosclerosis (hardening of the arteries), and heart disease. There are two parts to the study: a screening visit, and Phase II. During Phase II, the investigators will test patients after they are placed on a low salt diet and again after a high salt diet.

Eligible Conditions
  • High Blood Pressure
  • Insulin Resistance

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Genetic Variation at the Caveolin-1 Locus

Trial Design

2Treatment groups
Experimental Treatment
Group I: minor allele carriersExperimental Treatment3 Interventions
we will compare this arm with the major allele homozygous arm
Group II: major allele homozygousExperimental Treatment3 Interventions
we will compare this arm with the minor allele carrier arm
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Angiotensin II
2010
Completed Phase 4
~260
Norepinephrine
2014
Completed Phase 4
~1780

Find a Location

Who is running the clinical trial?

Brigham and Women's HospitalLead Sponsor
1,599 Previous Clinical Trials
11,462,394 Total Patients Enrolled
National Institutes of Health (NIH)NIH
2,679 Previous Clinical Trials
6,910,562 Total Patients Enrolled
National Heart, Lung, and Blood Institute (NHLBI)NIH
3,814 Previous Clinical Trials
47,290,755 Total Patients Enrolled

Frequently Asked Questions

~8 spots leftby Mar 2025