11C-JMJ-129 for Healthy Subjects
What You Need to Know Before You Apply
What is the purpose of this trial?
Background:PDE4D is a protein in the body that plays a role in thinking and depression. This protein may play a major role in disorders such as Alzheimer disease or major depressive disorder. To learn more about these disorders, researchers want to be able to detect levels of PDE4D in the brain. 11C-JMJ-129 is a new radiotracer (a radioactive substance that highlights parts of the body during imaging scans) that was developed to attach only to PDE4D.Objective:To test the new radiotracer 11C-JMJ-129 during imaging scans in healthy volunteers.Eligibility:Healthy people aged 18 years and older who had a screening assessment under protocol 01-M-0254.Design:Participants will have 2 to 4 clinic visits.Participants will be screened. They will have a physical exam. They will have blood tests and a test of their heart function.Participants will undergo 1 or more of these scans:A positron emission tomography (PET) scan of the whole body. The radiotracer will be injected through a tube placed in a vein in the arm. Participants will lie on a table while a donut-shaped machine passes over them. Blood will be drawn from the arm during this scan.A magnetic resonance imaging (MRI) scan of the brain. Participants will lie on a table that slides into a tube.A PET scan of the brain. These participants will be injected with the radiotracer. They will lie on a table with their head in the scanner.Participants will be called within 3 days after each PET scan for a check on their health.
Who Is on the Research Team?
Robert B Innis, M.D.
Principal Investigator
National Institute of Mental Health (NIMH)
Are You a Good Fit for This Trial?
This trial is for healthy adults over 18 who've completed a screening under protocol 01-M-0254. It's designed to test a new radiotracer, so participants should be willing to undergo various scans and have no health conditions that exclude them from imaging procedures.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Imaging
Participants undergo PET and MRI scans to study the brain uptake of 11C-JMJ-129 and perform kinetic modeling
Follow-up
Participants are monitored for safety and effectiveness after imaging scans
What Are the Treatments Tested in This Trial?
Interventions
- 11C-JMJ-129
Find a Clinic Near You
Who Is Running the Clinical Trial?
National Institute of Mental Health (NIMH)
Lead Sponsor