NAM + NMN for Healthy Adults
Trial Summary
Will I have to stop taking my current medications?
You may need to stop taking certain supplements, especially those containing niacin, nicotinic acid, nicotinamide, or herbal supplements, at least 14 days before starting the trial. If you are using a supplement with NAM, niacin, NMN, or NR, you must stop it at least 2 weeks before joining. Other medications like anabolic steroids, certain performance-enhancing drugs, and some recreational drugs are also prohibited.
What data supports the effectiveness of the drug Nicotinamide Mononucleotide (NMN) for healthy adults?
Is the combination of NAM and NMN safe for healthy adults?
How does the drug NAM + NMN differ from other treatments for age-related conditions?
The drug NAM + NMN is unique because it combines nicotinamide and nicotinamide mononucleotide, which are precursors to nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme for metabolism. This combination aims to increase NAD+ levels, potentially counteracting age-related changes and improving metabolic health, which is different from other treatments that may not target NAD+ levels directly.145910
What is the purpose of this trial?
We are doing this research to learn how healthy younger and older adults use two forms of vitamin B3-called nicotinamide mononucleotide (NMN) and nicotinamide (NAM)-to make NAD+. NAD+ is a natural substance that cells need for energy and other important processes. Our goal is to find out how these NAD precursors are absorbed and metabolized and how they raise NAD+ in different tissues.Who can join? Healthy adults men and women aged 18 to 40 (younger group) or 65 and older (older group) Participants with a body mass index ranging between 19 and 35 No major health issues like diabetes or severe kidney diseaseWhat will happen? Participants will take labeled or unlabeled NMN or NAM by mouth every day for 14 days.Researchers will collect blood, urine, and stool samples. Researchers also do a small muscle biopsy (under local numbing) twice to check how these NAD precursors raise NAD+ in muscle.Why is this important? NAD+ levels may drop as people age, and this drop could affect overall health and energy in cells.A better understanding of how NMN and NAM are metabolized in the body to raise NAD+ levels in both younger and older adults may help us optimize dosing and strategies for raising NAD in older people.Possible benefits and risks:Participants may not get any direct health benefit from this study; the main goal is to gather new knowledge.NMN and NAM appear safe in the doses used. A muscle biopsy may cause soreness or bruising.Researchers will monitor participants closely for any side effects throughout the study.
Research Team
Shalender Bhasin, MB, BS
Principal Investigator
Brigham and Women's Hosptial
Eligibility Criteria
Healthy adults aged 18-40 or 65+ with a BMI of 19-35 can join this study. They must not have major health issues like diabetes or severe kidney disease. The trial aims to understand how the body uses vitamin B3 forms (NMN and NAM) to produce NAD+, which is vital for cellular energy.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Intervention
Participants receive daily doses of NMN or NAM for 14 days with detailed sampling on Days 1 and 14
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Nicotinamide
- Nicotinamide Mononucleotide
Find a Clinic Near You
Who Is Running the Clinical Trial?
Metro International Biotech, LLC
Lead Sponsor