L-glutamine for Diverticulosis
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests whether L-glutamine, an amino acid, is safe and effective for individuals with diverticulosis, a condition where small pouches form in the colon. Participants will take L-glutamine powder twice daily for 48 weeks to assess its impact on their condition. The trial seeks individuals who have had a colonoscopy showing 5-10 pouches in specific parts of the colon but no more than 40 pouches overall. Those with doctor-confirmed diverticulosis who meet these criteria may find this trial suitable. As a Phase 1 trial, the research focuses on understanding how the treatment works in people, offering participants the chance to be among the first to receive this new treatment.
Do I need to stop my current medications to join the trial?
The trial information does not specify if you need to stop taking your current medications. However, you cannot have taken any form of glutamine supplement within 30 days before the screening visit.
Is there any evidence suggesting that L-glutamine is likely to be safe for humans?
Research has shown that L-glutamine is generally safe for people. As an amino acid, it helps build proteins in the body and supports both the immune system and digestion. Studies indicate it is not considered dangerous and usually doesn't cause serious health problems. However, some people might experience mild side effects like constipation, nausea, or headaches.
Long-term use of L-glutamine might alter how the body handles other amino acids and ammonia. It could also affect the immune system or tumor growth, though these effects are not fully understood yet. Overall, research suggests L-glutamine is safe for most people, but monitoring for any side effects is important. Always consult a healthcare provider before starting any new treatment.12345Why do researchers think this study treatment might be promising?
Most treatments for diverticulosis focus on managing symptoms through diet changes, fiber supplements, and sometimes antibiotics. But L-glutamine works differently by targeting gut health at a fundamental level. L-glutamine is an amino acid that helps strengthen the intestinal lining and reduce inflammation, which could address the underlying issues rather than just the symptoms. Researchers are excited about L-glutamine because it has the potential to improve gut integrity and overall digestive health, offering a novel approach compared to current strategies.
What evidence suggests that L-glutamine might be an effective treatment for diverticulosis?
Research has shown that L-glutamine can help maintain a healthy gut, which is important for people with diverticulosis. One study found that after just 14 days of taking glutamine, participants experienced a positive change in the balance of gut bacteria, suggesting that glutamine might improve gut health. In another study, L-glutamine reduced pain episodes in people with sickle cell disease over 48 weeks, indicating it might also ease symptoms in other conditions. While direct evidence for its effects on diverticulosis is not yet available, its benefits for gut health and symptom relief in other conditions are promising. Participants in this trial will receive L-glutamine oral powder, 15 grams twice daily for 48 weeks, to evaluate its effects.678910
Who Is on the Research Team?
Yutaka L Niihara, MD
Principal Investigator
Emmaus Medical, Inc.
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive L-glutamine oral powder 15 grams twice daily
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- L-glutamine
Find a Clinic Near You
Who Is Running the Clinical Trial?
Emmaus Medical, Inc.
Lead Sponsor