Hyperpolarized Xe129 MRI for COVID-19
PJ
Overseen ByPeter J Niedbalski, PhD
Age: 18+
Sex: Any
Trial Phase: Phase 1
Sponsor: University of Kansas Medical Center
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Trial Summary
What is the purpose of this trial?
The purpose of this study is to evaluate pulmonary function of patients recovering from mild, moderate, and severe COVID-19 disease using hyperpolarized 129Xe MRI.
Eligibility Criteria
This trial is for people who had COVID-19 and are in outpatient follow-up. They must be at least 10 days past the start of symptoms, without a fever, able to understand English or Spanish, and have an oxygen saturation of ≥88%. Pregnant individuals, those unable to fit into the MRI vest or hold their breath for about 15 seconds, under 18 years old, or with certain cognitive deficits cannot participate.Inclusion Criteria
The participant has a previous diagnosis of COVID-19 confirmed by COVID-19 PCR or antibody testing and is being seen for outpatient follow-up.
Subject is at least 10 days post-symptom-onset and do not have a fever (<99.5°).
Ability to read and understand English or Spanish
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Exclusion Criteria
Subject is pregnant or lactating
Subject does not fit into 129Xe vest coil used for MRI
You are unable to hold your breath for 15-16 seconds.
See 5 more
Timeline
Screening
Participants are screened for eligibility to participate in the trial
2-4 weeks
Imaging
Participants undergo hyperpolarized 129Xe MRI to evaluate pulmonary structure and function
1 day
1 visit (in-person)
Follow-up
Participants are monitored for long-term pulmonary function impairment
6 months
Periodic assessments
Treatment Details
Interventions
- Hyperpolarized Xe129
Trial Overview The study is testing hyperpolarized Xe129 MRI's ability to assess lung function in patients who've recovered from mild to severe COVID-19. It aims to provide insights on how well their lungs are working post-infection using this advanced imaging technique.
Participant Groups
1Treatment groups
Experimental Treatment
Group I: COVID-19 SurvivorsExperimental Treatment1 Intervention
Subjects recovering from COVID-19 disease will be imaged using hyperpolarized 129Xe MRI.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Kansas Medical Center
Lead Sponsor
Trials
527
Recruited
181,000+
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