Metformin for Chronic Obstructive Pulmonary Disease

(INSPIRE-COPD-E Trial)

Overseen By Jessica Shier

Age: 65+

Sex: Any

Trial Phase: Phase 1

Sponsor: Duke University

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this study is to investigate the safety and tolerability of Metformin and how it changes blood markers associated with aging in persons who have chronic obstructive pulmonary disease (COPD) who do not have diabetes.

Who Is on the Research Team?

Christopher Mosher, MD

Principal Investigator

Duke University

Are You a Good Fit for This Trial?

Inclusion Criteria

History of COPD defined by spirometry demonstrating FEV1/FVC < 70%

10 or more tobacco pack year history

I've had at least one severe or two moderate COPD flare-ups in the last year.

Exclusion Criteria

Metformin allergy

I have diabetes or am currently being treated with metformin.

I have a disability that prevents me from visiting the clinic in person.

What Are the Treatments Tested in This Trial?

Interventions

• Metformin

How Is the Trial Designed?

Group I: Metformin Experimental Treatment 1 Intervention

Metformin in COPD patients without diabetes

Who Is Running the Clinical Trial?

Duke University

Lead Sponsor

Trials

2,495

Recruited

5,912,000+

National Institute on Aging (NIA)

Collaborator

Trials

1,841

Recruited

28,150,000+