Lenvatinib, Pembrolizumab and Hypofractionated (Hypofx) External Beam Radiation Therapy (EBRT) Group for Endometrial Cancer

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
University of Miami, Miami, FLEndometrial Cancer+1 MoreLenvatinib - Drug
Eligibility
18+
Female
What conditions do you have?
Select

Study Summary

This trial tests combining drugs and radiation to stop cancer from spreading.

Eligible Conditions
  • Endometrial Cancer
  • Unresectable Endometrial Cancer

Treatment Effectiveness

Study Objectives

2 Primary · 2 Secondary · Reporting Duration: Up to 1 year

Up to 1 year
Recommended Phase 2 Dose (RP2D) of Lenvatinib
Up to 12 weeks
Number of Events of Treatment-Related Toxicity
Number of Reported Adverse Events
Overall Response Rate (ORR)

Trial Safety

Trial Design

1 Treatment Group

Lenvatinib, Pembrolizumab and Hypofractionated (Hypofx) External Beam Radiation ...
1 of 1

Experimental Treatment

18 Total Participants · 1 Treatment Group

Primary Treatment: Lenvatinib, Pembrolizumab and Hypofractionated (Hypofx) External Beam Radiation Therapy (EBRT) Group · No Placebo Group · Phase 1

Lenvatinib, Pembrolizumab and Hypofractionated (Hypofx) External Beam Radiation Therapy (EBRT) GroupExperimental Group · 3 Interventions: Lenvatinib, Pembrolizumab, Hypofractionated External Beam Radiation Therapy · Intervention Types: Drug, Drug, Radiation
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Lenvatinib
2005
Completed Phase 3
~3590
Pembrolizumab
2017
Completed Phase 3
~2200

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: up to 1 year

Who is running the clinical trial?

Aaron WolfsonLead Sponsor
Aaron Wolfson, MD, FACRPrincipal InvestigatorUniversity of Miami

Eligibility Criteria

Age 18+ · Female Participants · 8 Total Inclusion Criteria

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Frequently Asked Questions

Has the government sanctioned Lenvatinib, Pembrolizumab and Hypofx EBRT as a feasible medical treatment?

"Due to the limited amount of data confirming efficacy and safety, our team has judged Lenvatinib, Pembrolizumab and Hypofractionated (Hypofx) External Beam Radiation Therapy (EBRT) Group on a 1-3 scale as a 1." - Anonymous Online Contributor

Unverified Answer

Are there still enrollees being incorporated into this research project?

"Clinicaltrials.gov data indicates that this medical study, which was initially posted on February 1st 2023, is not currently seeking patients. Unfortunately, enrolment for the trial has been suspended; however 3467 other trials are still actively recruiting individuals." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.