Veverimer for Osteopenia
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this clinical trial is to learn if veverimer will reduce urinary net acid excretion leading to reduced bone resorption in healthy adults with osteopenia. The main questions it aims to answer are:
* How much does each dose of veverimer (vs. placebo) reduce 24-hr urinary net acid excretion.
* Describe the safety of veverimer based on changes in serum bicarbonate and potassium.
* Assess the changes in bone resorption.
* Assess the changes in bone formation.
* Explore the effect of veverimer on physical performance.
Participants will:
* Take veverimer or placebo every day or every other day for 8 weeks
* Visit the clinic a total of 8 times (including screening) for checkups and testing
* Keep a medication diary tracking each day they take the study drug
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants take veverimer or placebo every day or every other day for 8 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Veverimer
How Is the Trial Designed?
3
Treatment groups
Experimental Treatment
Placebo Group
Find a Clinic Near You
Who Is Running the Clinical Trial?
Tufts Medical Center
Lead Sponsor
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Collaborator
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