AVA6103 for Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This is a first-in-human (FIH), Phase 1 open-label, multicenter dose escalation study investigating AVA6103 monotherapy administered intravenously in patients with locally advanced (unresectable) or metastatic solid tumors that are likely to be FAP positive. The study consists of an initial Phase 1a dose escalation portion and a subsequent Phase 1b dose expansion portion upon completion of the dose escalation portion.
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Phase 1a Dose Escalation
Participants receive escalating doses of AVA6103 in two schedules: Day 1 of a 21-day cycle (Q3W) and Day 1 of a 14-day cycle (Q2W) until disease progression, unacceptable toxicities, withdrawal, or death.
Phase 1b Dose Expansion
Participants receive AVA6103 at the recommended phase 2 dose until disease progression, unacceptable toxicities, withdrawal, or death.
Follow-up
Participants are monitored for safety and effectiveness after treatment, including assessment of adverse events and survival outcomes.
What Are the Treatments Tested in This Trial?
Interventions
- AVA6103
How Is the Trial Designed?
3
Treatment groups
Experimental Treatment
Patients in this arm will receive AVA6103 at the recommended phase 2 dose, until disease progression, unacceptable toxicities, withdrawal from treatment for other reasons, or death, whichever occurs first.
Patients in this arm will receive escalating doses of AVA6103 Q3W until disease progression, unacceptable toxicities, withdrawal from treatment for other reasons, or death, whichever occurs first.
Patients in this arm will receive escalating doses of AVA6103 Q2W until disease progression, unacceptable toxicities, withdrawal from treatment for other reasons, or death, whichever occurs first.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Avacta Life Sciences Ltd
Lead Sponsor
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