Fluorescent Nerve Imaging with Illuminare-1 for Prostate Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests Illuminare-1, a substance that makes nerves glow, in prostate cancer surgeries. It aims to find a safe dose that helps surgeons see and avoid damaging nerves. The study will compare surgeries with and without this glowing guidance.
Do I need to stop taking my current medications for this trial?
The trial protocol does not specify if you need to stop all current medications. However, you must avoid phototoxic drugs like St. John's wort and certain antibiotics. If you can safely stop these, you must do so for 5 half-lives before and 48 hours after taking Illuminare-1.
Will I have to stop taking my current medications?
You may need to stop taking certain medications, especially if they are phototoxic (make your skin sensitive to light) like St. John's wort or certain antibiotics. If it's safe, you'll need to stop these medications for a period before and after receiving Illuminare-1.
What safety data exists for Fluorescent Nerve Imaging with Illuminare-1 for Prostate Cancer?
The provided research does not directly address the safety data for Illuminare-1 or its related names. However, it discusses the use of photodynamic therapy (PDT) and photodynamic diagnosis (PDD) in prostate and other cancers. These studies highlight the potential benefits of PDT and PDD in improving tumor visualization and reducing recurrence, but specific safety data for Illuminare-1 is not mentioned. Further research specifically on Illuminare-1 would be needed to determine its safety profile.12345
Is fluorescent nerve imaging with Illuminare-1 safe for humans?
The research does not provide specific safety data for Illuminare-1 or related technologies like D-Light C PDD in humans, but photodynamic therapy (PDT) has been studied in prostate cancer and other conditions, showing potential for improved tumor visualization and reduced recurrence with careful dosimetry to minimize damage to surrounding tissues.12345
Is the drug Illuminare-1 a promising treatment for prostate cancer?
How does the drug Illuminare-1 differ from other treatments for prostate cancer?
Illuminare-1 is unique because it uses a fluorescent dye to help surgeons see nerves more clearly during prostate cancer surgery, reducing the risk of nerve damage. This approach is different from traditional methods as it provides real-time visualization of nerves, which is not possible with standard imaging techniques.678910
What data supports the idea that Fluorescent Nerve Imaging with Illuminare-1 for Prostate Cancer is an effective treatment?
The available research shows that using fluorescent imaging techniques, like those with Illuminare-1, can improve the visualization of tumor margins during prostate cancer surgery. This helps surgeons remove more of the cancerous tissue, which can reduce the chances of the cancer coming back. One study highlighted that a similar approach using a targeted photodynamic agent allowed for better tumor detection and removal compared to traditional methods. This method also helped identify cancer cells in lymph nodes, which is crucial for effective treatment. Overall, these findings suggest that fluorescent imaging can enhance surgical outcomes by making it easier to see and remove cancerous tissues.211121314
What data supports the effectiveness of the treatment Illuminare-1 for prostate cancer?
Research shows that photodynamic therapy (PDT), which uses light-sensitive drugs to kill cancer cells, can improve surgery outcomes by helping doctors see and remove more cancer tissue. This approach has been shown to reduce tumor recurrence and improve survival in prostate cancer, suggesting that similar treatments like Illuminare-1 could be effective.211121314
Who Is on the Research Team?
Timothy Donahue, MD
Principal Investigator
Memorial Sloan Kettering Cancer Center
Are You a Good Fit for This Trial?
This trial is for adults over 18 who can consent and are scheduled for a specific prostate cancer surgery. It's not for those with prior pelvic procedures, recent investigational drugs use, significant kidney or liver issues, exposure to phototoxic drugs without proper washout period, or nervous system diseases.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Dose Escalation
Participants receive increasing doses of Illuminare-1 to determine the dose that causes nerve structures to fluoresce with few or mild side effects
Pharmacokinetics
Tests are conducted to study the absorption, distribution, and elimination of Illuminare-1 in the body
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Illuminare-1
- Karl Storz D-Light C photodynamic diagnostic (PDD)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Memorial Sloan Kettering Cancer Center
Lead Sponsor
Illuminare Biotechnologies
Collaborator