Enzyme Cocktails for Gut Health
(ElZyme Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to determine if two different enzyme cocktails can improve gut health in adults with mild to moderate digestive discomfort. Participants will take the enzyme cocktails and report their experiences over four weeks, comparing this to another four weeks when they take a placebo (a non-active substance). The trial seeks individuals who frequently experience bloating or minor stomach issues but have not taken antibiotics or digestive supplements in the past three months.
As an unphased trial, this study offers participants the chance to contribute to the scientific understanding of digestive health solutions.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are using immunosuppressive agents or have taken antibiotics, prebiotics, probiotics, or digestive enzyme supplements in the past 3 months.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that enzyme mixtures, like those in this trial, are generally safe for people. Digestive enzymes have helped with indigestion and improved sleep in past patients. Studies also indicate that food safety standards consider the ingredients in these enzyme mixtures safe.
Although limited data exists specifically for this trial's enzyme mixtures, these treatments are usually well-tolerated. Similar enzyme products have not reported major negative effects. Participants in previous studies have not shown any major safety issues, and any side effects are typically mild, if they occur at all.
In summary, enzyme mixtures like those in this study are usually safe and well-tolerated by most people. However, discussing any concerns with a healthcare provider before joining a trial is always important.12345Why are researchers excited about this trial's treatments?
Researchers are excited about these enzyme cocktails because they offer a new approach to improving gut health. Unlike traditional treatments that mostly focus on diet changes or probiotics, these cocktails use a blend of specialized enzymes designed to enhance digestion and nutrient absorption directly. This potentially leads to faster and more effective results for digestive issues. Additionally, the cocktails could offer personalized treatment options, as different enzyme combinations might be tailored to individual digestive needs, paving the way for more customized gut health solutions.
What evidence suggests that this trial's treatments could be effective for improving gut health?
Research has shown that digestive enzymes can reduce symptoms like bloating and stomach swelling. One study found that these enzymes effectively eased symptoms of functional dyspepsia, a type of stomach discomfort, and improved sleep quality. In this trial, participants will receive either Enzyme Cocktail A or Enzyme Cocktail B. Both are designed to enhance gut health by breaking down food more efficiently, potentially relieving mild to moderate stomach issues. Previous patients using similar enzyme treatments experienced better gut health. These enzymes aid digestion, leading to less discomfort and improved overall gut health.13456
Are You a Good Fit for This Trial?
This trial is for healthy adults experiencing mild to moderate stomach discomfort. Participants must be willing to take enzyme cocktails or placebos and complete weekly questionnaires about their gut health. They also need to provide stool samples at the beginning and end of each treatment phase.Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either the enzyme cocktail or placebo for 4 weeks, with weekly questionnaires and stool sample collection at the start and end of each treatment period
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Enzyme Cocktail A
- Enzyme Cocktail B
Find a Clinic Near You
Who Is Running the Clinical Trial?
The Archer-Daniels-Midland Company
Lead Sponsor
University of North Texas, Denton, TX
Collaborator