Neuro-Intermuscular Coordination Enhancement for Stroke
(NICE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The objective of this study is to develop Neuro-Intermuscular Coordination Enhancement (NICE) rehabilitation, a novel neuromuscular control signal-guided strategy that visually guides stroke patients to individually activate groups of synergistic muscles through human-machine interaction. Ultimately, the development will lead to better clinical motor recovery, better quality of life, and lowered healthcare costs associated with the impairment.
Who Is on the Research Team?
Jinsook Roh, PhD
Principal Investigator
University of Houston
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo either neuromuscular-coordination guided exercise (NICE) or force-guided exercise for rehabilitation
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- NICE Rehabilitation Through Human-Machine Interaction
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Post-stroke participants will perform a center-out task by generating isometric contractions of multiple muscles to move the cursor on a screen while electromyographic (EMG) responses are recorded. Activation of each muscle (or muscle group) will be mapped to 1 of 4 directions within the multi-dimensional cursor space. We will derive the cursor position in real time using EMGs recorded from multiple arm muscles.
Post-stroke participants will perform a center-out task by generating isometric force to move the cursor on a screen. Participants will generate isometric force, which will move their cursor on the monitor. They will be trained to match one of the four force targets on display. We will derive the cursor position in real time using three forces (Fx, Fy, and Fz) measured at the load cell.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Houston
Lead Sponsor
The University of Texas Health Science Center, Houston
Collaborator
TIRR Memorial Hermann
Collaborator
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