Acetazolamide for Altitude Sickness
What You Need to Know Before You Apply
What is the purpose of this trial?
High altitude travel can lead to inflammation in the body and activation of innate immune cells. The investigators' prior research demonstrates that 1 to 3 days at 3800 m elevation leads to increased expression of genes in blood cells that code for proteins that signal cell damage (damage associated molecular patterns (DAMPs)), cell receptors involved in innate immune responses, as well as increases in monocyte and neutrophil cells which promote inflammation. This study will investigate the potential mechanisms underlying these effects using the drug Acetazolamide, a carbonic anhydrase inhibitor which is known to reduce symptoms of Acute Mountain Sickness.
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Testing
Participants complete baseline testing at low altitude, including physiological parameters and ventilatory chemoreflex testing
Treatment
Participants receive Acetazolamide or placebo starting 2 days before ascent and continue for 3 days at high altitude
Follow-up
Participants are monitored for immune response and acute mountain sickness symptoms after return to baseline elevation
What Are the Treatments Tested in This Trial?
Interventions
- Acetazolamide
How Is the Trial Designed?
2
Treatment groups
Active Control
Placebo Group
Acetazolamide is administered orally in pill form at a 125 mg dose taken twice per day (morning and evening) starting 2 days before ascent to high altitude and each day while at high altitude.
This group will not be provided ACZ. Instead, participants will take a placebo compound in pill form resembling ACZ on the same schedule as the ACZ treatment.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Riverside
Lead Sponsor
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