Amisulpride for Addiction

PL
Overseen ByPatrick L Purdon, PhD

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this study is to evaluate whether medications used in peri-procedural clinical settings can modulate drug liking.

Are You a Good Fit for This Trial?

This trial is for individuals with an ASA physical status of I, II, or III who are scheduled for surgery or a procedure where they will receive up to 3 mcg/kg IBW of fentanyl. It's not specified who can't join the trial.

Inclusion Criteria

My health is good to moderately impaired according to the ASA.
I am expected to receive fentanyl for my upcoming surgery.

Exclusion Criteria

Craniofacial abnormalities
Known or suspected difficult intubation or mask ventilation
Allergies or hypersensitivities to amisulpride or fentanyl
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Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive the study drug or placebo prior to fentanyl administration before their procedure

1 day
1 visit (in-person)

Monitoring

Participants are monitored for changes in drug liking and sedation ratings, as well as EEG band power

1 hour
Continuous monitoring during procedure

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Amisulpride

Trial Overview

The study is testing whether Amisulpride, compared to a placebo, affects how much patients like the drugs they're given during and after surgery. The goal is to understand if this medication can influence drug liking in a clinical setting.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Placebo Group

Group I: DrugExperimental Treatment1 Intervention
Group II: PlaceboPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Stanford University

Lead Sponsor

Trials
2,527
Recruited
17,430,000+