← Back to Search

Radiation Therapy

Antimicrobial Therapy + SBRT for Lung Cancer

Phase < 1
Recruiting
Led By Steven Feigenberg, MD
Research Sponsored by Abramson Cancer Center at Penn Medicine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patient is planned to receive Stereotactic Body Radiotherapy (SBRT) to a biopsy-proven NSCLC
Patient capable of giving informed consent
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years
Awards & highlights

Study Summary

This trial is testing whether adding vancomycin to SBRT increases the effectiveness of SBRT by measuring the Th1 immune response.

Who is the study for?
This trial is for adults who can consent and are set to receive SBRT for confirmed NSCLC. It's not open to those with chronic constipation, recent use of steroids or immunosuppressants, antibiotics, antifungals, antivirals, or chemotherapy. People with uncontrolled GI disorders, certain infections or a history of major GI surgery aren't eligible.Check my eligibility
What is being tested?
The study tests if adding vancomycin (an antibiotic) to SBRT boosts the Th1 immune response in early-stage non-small cell lung cancer patients by measuring specific immune signals like IFN gamma after treatment.See study design
What are the potential side effects?
Potential side effects may include typical reactions to antibiotics such as stomach upset and diarrhea. SBRT might cause localized pain, skin changes at the radiation site, fatigue and rarely more serious complications.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am scheduled for targeted radiation therapy for my lung cancer.
Select...
I understand the details of the trial and can agree to participate.
Select...
I am 18 years old or older.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Th1 immune response measured by cytokine expression (IFN gamma).

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Arm 1 - ExperimentalExperimental Treatment2 Interventions
Group II: Arm 2 - Control ArmActive Control2 Interventions
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Vancomycin
2005
Completed Phase 4
~7930
Stereotactic Body Radiation Therapy (SBRT)
2018
Completed Phase 2
~740

Find a Location

Who is running the clinical trial?

Abramson Cancer Center at Penn MedicineLead Sponsor
385 Previous Clinical Trials
144,861 Total Patients Enrolled
Abramson Cancer Center of the University of PennsylvaniaLead Sponsor
359 Previous Clinical Trials
105,055 Total Patients Enrolled
Steven Feigenberg, MDPrincipal InvestigatorAbramson Cancer Center at Penn Medicine
4 Previous Clinical Trials
112 Total Patients Enrolled

Media Library

Stereotactic Body Radiation Therapy (SBRT) (Radiation Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT03546829 — Phase < 1
Non-Small Cell Lung Cancer Research Study Groups: Arm 1 - Experimental, Arm 2 - Control Arm
Non-Small Cell Lung Cancer Clinical Trial 2023: Stereotactic Body Radiation Therapy (SBRT) Highlights & Side Effects. Trial Name: NCT03546829 — Phase < 1
Stereotactic Body Radiation Therapy (SBRT) (Radiation Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03546829 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there other investigations that have incorporated Vancomycin in the past?

"At present, 55 Vancomycin clinical trials are ongoing; 6 of which have reached Phase 3. Although Jupiter, Florida is the epicentre for research on this antibiotic, a total of 315 sites across the nation are running experiments with it."

Answered by AI

Are there any remaining openings for individuals to take part in this trial?

"Affirmative. Information hosted on clinicaltrials.gov attests that this trial, which was originally posted on April 24th 2018, is actively seeking participants. Solely one medical centre needs to recruit 40 individuals for the study."

Answered by AI

What medical conditions has Vancomycin been instrumental in alleviating?

"Vancomycin is a suitable therapy for staphylococcal infections, colonization by the bacteria Staphyloccocus, and enterocolitis caused by S. Aureus."

Answered by AI

How many participants are currently enrolled in this clinical examination?

"Affirmative, the clinicaltrials.gov repository indicates that this medical trial is actively recruiting participants. The posting was originally published on April 24th 2018 and has been updated most recently on November 1st 2022. Forty patients need to be recruited from a single location for this study."

Answered by AI
~13 spots leftby Dec 2026