Vitaly Margulis, M.D.: Urology ...

Dr. Vitaly Margulis

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University of Texas Southwestern Medical Center

Studies Kidney Cancer
Studies Bladder Cancer
7 reported clinical trials
20 drugs studied

Area of expertise

1

Kidney Cancer

Vitaly Margulis has run 3 trials for Kidney Cancer. Some of their research focus areas include:

Stage I
Stage II
Stage III
2

Bladder Cancer

Vitaly Margulis has run 3 trials for Bladder Cancer. Some of their research focus areas include:

cN+
radiologic complete response
Stage II

Affiliated Hospitals

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University Of Texas Southwestern Medical Center

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UT Southwestern

Clinical Trials Vitaly Margulis is currently running

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Metabolic Tracers

for Kidney Cancer

The purpose of this study is to understand the metabolism of cancers involving the kidney, including renal cell carcinomas and urothelial cell carcinomas, and how kidney cancers use different types of fuel to support tumor growth. This study uses specially labeled nutrient tracers of compounds normally found circulating in the blood. The nutrients (glucose, fructose, glutamine, acetate, and lactate) are also found in common foods. A nutrient tracer will be given to the participants through an intravenous (IV) catheter during surgery or biopsy, and blood will be collected every 30 minutes during the infusion to monitor safety parameters and the nutrient tracers. The investigators will collect a tissue sample after the completion of surgery. Participants not having an infusion will have their tissue collected after surgery or biopsy. Participation in this study will not change patient care. All patients will receive standard of care treatment as determined by their doctors.

Recruiting

1 award

N/A

5 criteria

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Gemcitabine vs Water Irrigation

for Urothelial Cancer

There is a high rate of intravesical (bladder) recurrence following extirpative surgery for upper tract urothelial carcinoma. There is no single established standard of care for prevention of intravesical recurrence; however, one protocol in common use involves the use of intravesical gemcitabine instilled into the bladder during surgery and prior to entry into the bladder. There are barriers to the use of gemcitabine, especially at lower volume centers. Some evidence suggests that intravesical irrigation with sterile water has equivalent efficacy to intravesical chemotherapy in prevention of recurrent bladder cancer following transurethral resection of bladder tumors (TURBT). This study is intended to compare recurrence rates using intravesical gemcitabine (as a pseudo-standard of care) and continuous bladder irrigation with sterile water.

Recruiting

2 awards

Phase 3

5 criteria

More about Vitaly Margulis

Clinical Trial Related

6 years of experience running clinical trials · Led 7 trials as a Principal Investigator · 6 Active Clinical Trials

Treatments Vitaly Margulis has experience with

  • Padeliporfin VTP
  • Lenvatinib
  • Pembrolizumab
  • 13C-Acetate
  • 13C-Fructose
  • 13C-Glucose

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