Dr. Ticiana A. Leal
Claim this profileUniversity of Wisconsin Hospital and Clinics
Expert in Non-Small Cell Lung Cancer
Expert in Lung Cancer
17 reported clinical trials
24 drugs studied
Area of expertise
1Non-Small Cell Lung Cancer
Global LeaderStage III
Stage IV
Stage II
2Lung Cancer
Global LeaderStage III
Stage IV
Stage II
Affiliated Hospitals
Clinical Trials Ticiana A. Leal is currently running
Osimertinib + Bevacizumab
for Lung Cancer
This phase III trial compares the effect of bevacizumab and osimertinib combination vs. osimertinib alone for the treatment of non-small cell lung cancer that has spread outside of the lungs (stage IIIB-IV) and has a change (mutation) in a gene called EGFR. The EGFR protein is involved in cell signaling pathways that control cell division and survival. Sometimes, mutations in the EGFR gene cause EGFR proteins to be made in higher than normal amounts on some types of cancer cells. This causes cancer cells to divide more rapidly. Osimertinib may stop the growth of tumor cells by blocking EGFR that is needed for cell growth in this type of cancer. Bevacizumab is in a class of medications called antiangiogenic agents. It works by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of tumor. Giving osimertinib with bevacizumab may control cancer for longer and help patients live longer as compared to osimertinib alone.
Recruiting2 awards Phase 331 criteria
Osimertinib
for Non-Small Cell Lung Cancer
This phase II trial studies how well osimertinib works in treating patients with non-small cell lung cancer with EGFR exon 20 insertion mutation that is stage IIIB-IV or has come back after a period of improvement (recurrent). Osimertinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Recruiting1 award Phase 242 criteria
More about Ticiana A. Leal
Clinical Trial Related5 years of experience running clinical trials · Led 17 trials as a Principal Investigator · 9 Active Clinical TrialsTreatments Ticiana A. Leal has experience with
- Carboplatin
- Talazoparib
- Bevacizumab
- Atezolizumab
- Cisplatin
- Pemetrexed
Breakdown of trials Ticiana A. Leal has run
Non-Small Cell Lung Cancer
Lung Cancer
Skin Cancer
Uterine Tumors
Cancer
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