Dr. Shivani Upadhyay
Claim this profileSanta Barbara Cottage Hospital
Studies Cancer
Studies Burkitt Lymphoma
4 reported clinical trials
23 drugs studied
Affiliated Hospitals
Clinical Trials Shivani Upadhyay is currently running
Inotuzumab Ozogamicin
for Acute Lymphoblastic Leukemia
This phase III trial studies whether inotuzumab ozogamicin added to post-induction chemotherapy for patients with High-Risk B-cell Acute Lymphoblastic Leukemia (B-ALL) improves outcomes. This trial also studies the outcomes of patients with mixed phenotype acute leukemia (MPAL), and B-lymphoblastic lymphoma (B-LLy) when treated with ALL therapy without inotuzumab ozogamicin. Inotuzumab ozogamicin is a monoclonal antibody, called inotuzumab, linked to a type of chemotherapy called calicheamicin. Inotuzumab attaches to cancer cells in a targeted way and delivers calicheamicin to kill them. Other drugs used in the chemotherapy regimen, such as cyclophosphamide, cytarabine, dexamethasone, doxorubicin, daunorubicin, methotrexate, leucovorin, mercaptopurine, prednisone, thioguanine, vincristine, and pegaspargase or calaspargase pegol work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. This trial will also study the outcomes of patients with mixed phenotype acute leukemia (MPAL) and disseminated B lymphoblastic lymphoma (B-LLy) when treated with high-risk ALL chemotherapy. The overall goal of this study is to understand if adding inotuzumab ozogamicin to standard of care chemotherapy maintains or improves outcomes in High Risk B-cell Acute Lymphoblastic Leukemia (HR B-ALL). The first part of the study includes the first two phases of therapy: Induction and Consolidation. This part will collect information on the leukemia, as well as the effects of the initial treatment, to classify patients into post-consolidation treatment groups. On the second part of this study, patients with HR B-ALL will receive the remainder of the chemotherapy cycles (interim maintenance I, delayed intensification, interim maintenance II, maintenance), with some patients randomized to receive inotuzumab. The patients that receive inotuzumab will not receive part of delayed intensification. Other aims of this study include investigating whether treating both males and females with the same duration of chemotherapy maintains outcomes for males who have previously been treated for an additional year compared to girls, as well as to evaluate the best ways to help patients adhere to oral chemotherapy regimens. Finally, this study will be the first to track the outcomes of subjects with disseminated B-cell Lymphoblastic Leukemia (B-LLy) or Mixed Phenotype Acute Leukemia (MPAL) when treated with B-ALL chemotherapy.
Recruiting2 awards Phase 3
Health Information Collection
for Childhood Cancer
This study gathers health information for the Project: Every Child for younger patients with cancer. Gathering health information over time from younger patients with cancer may help doctors find better methods of treatment and on-going care.
Recruiting1 award N/A10 criteria
More about Shivani Upadhyay
Clinical Trial Related6 years of experience running clinical trials · Led 4 trials as a Principal Investigator · 2 Active Clinical TrialsTreatments Shivani Upadhyay has experience with
- Cyclophosphamide
- Cytarabine
- Dexamethasone
- Doxorubicin Hydrochloride
- Mercaptopurine
- Methotrexate
Breakdown of trials Shivani Upadhyay has run
Cancer
Burkitt Lymphoma
B-Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Shivani Upadhyay specialize in?
Shivani Upadhyay focuses on Cancer and Burkitt Lymphoma. In particular, much of their work with Cancer has involved treating patients, or patients who are undergoing treatment.
Is Shivani Upadhyay currently recruiting for clinical trials?
Yes, Shivani Upadhyay is currently recruiting for 2 clinical trials in Santa Barbara California. If you're interested in participating, you should apply.
Are there any treatments that Shivani Upadhyay has studied deeply?
Yes, Shivani Upadhyay has studied treatments such as Cyclophosphamide, Cytarabine, Dexamethasone.
What is the best way to schedule an appointment with Shivani Upadhyay?
Apply for one of the trials that Shivani Upadhyay is conducting.
What is the office address of Shivani Upadhyay?
The office of Shivani Upadhyay is located at: Santa Barbara Cottage Hospital, Santa Barbara, California 93102 United States. This is the address for their practice at the Santa Barbara Cottage Hospital.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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