Dr. Sarah J. Sinclair
Claim this profileLafayette Family Cancer Center-EMMC
Expert in Breast Cancer
Expert in Lung Cancer
80 reported clinical trials
157 drugs studied
Area of expertise
1Breast Cancer
Global LeaderHER2 positive
ER positive
Stage IV
2Lung Cancer
Global LeaderStage IV
Stage III
Stage II
Affiliated Hospitals
Clinical Trials Sarah J. Sinclair is currently running
Lomustine + Standard Therapy
for Glioblastoma
This phase III trial compares the effect of adding lomustine to standard chemotherapy with temozolomide and radiation therapy versus temozolomide and radiation therapy alone in shrinking or stabilizing newly diagnosed MGMT methylated glioblastoma. MGMT methylated tumors are more likely to respond to temozolomide chemotherapy. Temozolomide is in a class of medications called alkylating agents. It works by damaging the cell's DNA and may kill tumor cells and slow down or stop tumor growth. Lomustine is a chemotherapy drug and in a class of medications called alkylating agents. It damages the cell's DNA and may kill tumor cells. Radiation therapy uses high energy x-ray photons to kill tumor cells and shrink tumors. Adding lomustine to standard chemotherapy with temozolomide and radiation therapy may shrink or stabilize glioblastoma.
Recruiting2 awards Phase 34 criteria
Selumetinib + Olaparib
for Ovarian and Endometrial Cancer
This phase II ComboMATCH treatment trial compares selumetinib plus olaparib to selumetinib alone in women with endometrial or ovarian (fallopian tube and primary peritoneal) cancer that has come back (recurrent) or that remains despite treatment (persistent) and harbors a mutation in the RAS pathway. Selumetinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Olaparib is an inhibitor of PARP, an enzyme that helps repair deoxyribonucleic acid (DNA) when it becomes damaged. Blocking PARP may help keep tumor cells from repairing their damaged DNA, causing them to die. PARP inhibitors are a type of targeted therapy. The addition of olaparib to selumetinib could increase the percentage of tumors that shrink as well as lengthen the time that the tumors remain stable (without progression) as compared to selumetinib alone.
Recruiting1 award Phase 2
More about Sarah J. Sinclair
Clinical Trial Related6 years of experience running clinical trials · Led 80 trials as a Principal Investigator · 27 Active Clinical TrialsTreatments Sarah J. Sinclair has experience with
- Paclitaxel
- Pembrolizumab
- Carboplatin
- Fluorouracil
- Olaparib
- Radiation Therapy
Breakdown of trials Sarah J. Sinclair has run
Breast Cancer
Lung Cancer
Cancer
Non-Small Cell Lung Cancer
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Sarah J. Sinclair specialize in?
Sarah J. Sinclair focuses on Breast Cancer and Lung Cancer. In particular, much of their work with Breast Cancer has involved HER2 positive patients, or patients who are ER positive.
Is Sarah J. Sinclair currently recruiting for clinical trials?
Yes, Sarah J. Sinclair is currently recruiting for 27 clinical trials in Brewer Maine. If you're interested in participating, you should apply.
Are there any treatments that Sarah J. Sinclair has studied deeply?
Yes, Sarah J. Sinclair has studied treatments such as Paclitaxel, Pembrolizumab, Carboplatin.
What is the best way to schedule an appointment with Sarah J. Sinclair?
Apply for one of the trials that Sarah J. Sinclair is conducting.
What is the office address of Sarah J. Sinclair?
The office of Sarah J. Sinclair is located at: Lafayette Family Cancer Center-EMMC, Brewer, Maine 04412 United States. This is the address for their practice at the Lafayette Family Cancer Center-EMMC.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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