Robert F. Spiera, MD - Rheumatology | HSS

Dr. Robert Spiera, MD

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Hospital for Special Surgery

Studies Systemic Sclerosis
Studies Scleroderma
6 reported clinical trials
9 drugs studied

Affiliated Hospitals

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Hospital For Special Surgery

Clinical Trials Robert Spiera, MD is currently running

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Belimumab + Rituximab

for Systemic Sclerosis

This is a 52 week, single center, randomized, double-blind, placebo-controlled study. After patients maintain a stable dose of Mycophenolate Mofetil (MMF) for at least 1 month, they will be randomized to treatment with either Belimumab \& Rituximab or placebo.Patients in both groups will be on background MMF for the entirety of the study. Belimumab will be administered subcutaneously and Rituximab intravenously. Placebo injections and infusions will be of normal saline. Randomization will be done in a 2:1 manner to favor the treatment group. It is hypothesized that that Rituximab and Belimumab combination therapy with Mycophenolate Mofetil background therapy will improve fibrosis in SSc skin when compared to treatment with placebo and Mycophenolate Mofetil in a group of patients with early dcSSc.
Recruiting0 awards Phase 25 criteria
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Abatacept

for Giant Cell Arteritis

This randomized, double-blind, placebo-controlled trial will seek to determine the efficacy of abatacept in GCA. To examine this objective, 62 eligible patients who have newly diagnosed or relapsing GCA within 8 weeks prior to screening will be randomized at a 1:1 ratio to receive subcutaneous abatacept 125mg/week or placebo. Patients who achieve remission will remain on their blinded assignment for 12 months at which time abatacept/placebo will be stopped. Patients who do not achieve remission by Month 3, who experience a relapse within the first 12 months will have the option of receiving open-label abatacept for a maximum of 12 months.
Recruiting1 award Phase 36 criteria

More about Robert Spiera, MD

Clinical Trial Related6 years of experience running clinical trials · Led 6 trials as a Principal Investigator · 4 Active Clinical Trials
Treatments Robert Spiera, MD has experience with
  • Belimumab
  • Placebo
  • MMF
  • Placebo Infusion
  • Placebo Subcutaneous Injection
  • Rituximab

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