Dr. Nicole P. Chappell
Claim this profileGeorge Washington University Medical Center
Studies Uterine Cancer
Studies Ovarian Cancer
5 reported clinical trials
16 drugs studied
Area of expertise
1Uterine Cancer
Stage I
HER2 positive
Stage II
2Ovarian Cancer
BRCA1 positive
Stage II
Stage III
Affiliated Hospitals
Clinical Trials Nicole P. Chappell is currently running
Herceptin Hylecta or Phesgo + Chemotherapy
for Uterine Cancer
This phase III trial tests whether adding trastuzumab and hyaluronidase-oysk (Herceptin Hylecta \[TM\]) or pertuzumab, trastuzumab and hyaluronidase-zzxf (Phesgo \[TM\]) to the usual chemotherapy (paclitaxel and carboplatin) works to shrink tumors in patients with HER2 positive endometrial cancer. Trastuzumab and pertuzumab are monoclonal antibodies and forms of targeted therapy that attach to specific molecules (receptors) on the surface of tumor cells, known as HER2 receptors. When trastuzumab or pertuzumab attach to HER2 receptors, the signals that tell the cells to grow are blocked and the tumor cell may be marked for destruction by the body's immune system. Hyaluronidase is an endoglycosidase. It helps to keep pertuzumab and trastuzumab in the body longer, so that these medications will have a greater effect. Hyaluronidase also allows trastuzumab and trastuzumab/pertuzumab to be given by injection under the skin and shortens their administration time compared to trastuzumab or pertuzumab alone. Paclitaxel is a taxane and in a class of medications called antimicrotubule agents. It stops tumor cells from growing and dividing and may kill them. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of tumor cells. Giving Herceptin Hylecta or Phesgo in combination with paclitaxel and carboplatin may shrink the tumor and prevent the cancer from coming back in patients with HER2 positive endometrial cancer.
Recruiting2 awards Phase 3
Sentinel Lymph Node Mapping
for Endometrial Cancer
This phase III trial compares the effect of sentinel lymph node mapping to standard lymph node dissection in reducing the risk of swelling in the legs (lymphedema) in patients undergoing a hysterectomy for stage I endometrial cancer. Standard lymph node dissection removes lymph nodes around the uterus during a hysterectomy to look for spread of cancer from the uterus to nearby lymph nodes. Sentinel lymph node mapping uses a special dye and camera to look for cancer that may have spread to nearby lymph nodes. Comparing the results of the procedures may help doctors predict the risk of long-term swelling in the legs.
Recruiting2 awards Phase 3
More about Nicole P. Chappell
Clinical Trial Related7 years of experience running clinical trials · Led 5 trials as a Principal Investigator · 3 Active Clinical TrialsTreatments Nicole P. Chappell has experience with
- Bilateral Salpingectomy With Oophorectomy
- Bilateral Salpingectomy
- Olaparib
- Cediranib Maleate
- Capivasertib
- Durvalumab
Breakdown of trials Nicole P. Chappell has run
Uterine Cancer
Ovarian Cancer
Fallopian Tube Carcinosarcoma
Endometrial Adenocarcinoma
Endometrioid Carcinoma
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Nicole P. Chappell specialize in?
Nicole P. Chappell focuses on Uterine Cancer and Ovarian Cancer. In particular, much of their work with Uterine Cancer has involved Stage I patients, or patients who are HER2 positive.
Is Nicole P. Chappell currently recruiting for clinical trials?
Yes, Nicole P. Chappell is currently recruiting for 3 clinical trials in Washington District of Columbia. If you're interested in participating, you should apply.
Are there any treatments that Nicole P. Chappell has studied deeply?
Yes, Nicole P. Chappell has studied treatments such as Bilateral Salpingectomy with Oophorectomy, Bilateral Salpingectomy, Olaparib.
What is the best way to schedule an appointment with Nicole P. Chappell?
Apply for one of the trials that Nicole P. Chappell is conducting.
What is the office address of Nicole P. Chappell?
The office of Nicole P. Chappell is located at: George Washington University Medical Center, Washington, District of Columbia 20037 United States. This is the address for their practice at the George Washington University Medical Center.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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