Dr. Milan Chheda, M.D.
Claim this profileWashington University School of Medicine
Studies Brain Tumor
Studies Glioblastoma
11 reported clinical trials
21 drugs studied
Area of expertise
1Brain Tumor
SMO positive
PTCH1 positive
IDH negative
2Glioblastoma
germline
tumor
MGMT
Affiliated Hospitals
Clinical Trials Milan Chheda, M.D. is currently running
Multiple Targeted Therapies
for Meningioma
This trial studies four drugs to treat patients with worsening meningioma. These drugs work by blocking enzymes that the tumor cells need to grow. The trial focuses on patients whose tumors have specific genetic mutations.
Recruiting1 award Phase 210 criteria
Personalized DNA Vaccine + PD-1 Blockade
for Glioblastoma
This is a single institution, open-label, multi-arm, phase I study assessing the safety and immunogenicity of a personalized neoantigen-based personalized DNA vaccine combined with PD-1 blockade therapy in subjects with newly diagnosed, MGMT promoter unmethylated glioblastoma (GBM). Immune checkpoint blockade, specifically those targeting the PD-1/PD-L1 pathways, has shown efficacy in multiple solid and hematologic malignancies. Furthermore, as has been demonstrated in metastatic melanoma, combining PD-1/PD-L1 blockade with other immune checkpoint inhibitors has shown improved objective response rates, though there is a significant increase in serious immune-related adverse events. As such, current trials are exploring different doses, administration schedules, and immune checkpoint agents. One alternative approach, however, is to introduce a tumor-directed therapy such as a personalized neoantigen vaccine combined with these immune modulating agents (i.e. immune checkpoint blocking antibodies) to maximize the tumor-specific response but minimize the toxicity associated with increasing non-specific systemic immune activation by generating a potent and focused neoantigen specific immune response. This study will test the hypothesis that a personalized neoantigen DNA vaccine in combination with concurrent administration of immune checkpoint blockade therapy will enhance the magnitude and breadth of neoantigen-specific T cell responses while maintaining an acceptable safety profile. The overall goal of this study is to identify the optimal vaccine plus adjuvant platform that can be tested in a subsequent phase II study to determine the efficacy of a personalized neoantigen vaccine approach in patients with GBM.
Recruiting1 award Phase 1
More about Milan Chheda, M.D.
Clinical Trial Related3 years of experience running clinical trials · Led 11 trials as a Principal Investigator · 5 Active Clinical TrialsTreatments Milan Chheda, M.D. has experience with
- Retifanlimab
- Personalized Neoantigen DNA Vaccine
- Bevacizumab
- Epacadostat
- Radiation Therapy
- RhIL-7-hyFc
Breakdown of trials Milan Chheda, M.D. has run
Brain Tumor
Glioblastoma
Pineal Tumors
Spinal Cord Tumors
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Milan Chheda, M.D. specialize in?
Milan Chheda, M.D. focuses on Brain Tumor and Glioblastoma. In particular, much of their work with Brain Tumor has involved SMO positive patients, or patients who are PTCH1 positive.
Is Milan Chheda, M.D. currently recruiting for clinical trials?
Yes, Milan Chheda, M.D. is currently recruiting for 5 clinical trials in Saint Louis Missouri. If you're interested in participating, you should apply.
Are there any treatments that Milan Chheda, M.D. has studied deeply?
Yes, Milan Chheda, M.D. has studied treatments such as Retifanlimab, Personalized neoantigen DNA vaccine, Bevacizumab.
What is the best way to schedule an appointment with Milan Chheda, M.D.?
Apply for one of the trials that Milan Chheda, M.D. is conducting.
What is the office address of Milan Chheda, M.D.?
The office of Milan Chheda, M.D. is located at: Washington University School of Medicine, Saint Louis, Missouri 63110 United States. This is the address for their practice at the Washington University School of Medicine.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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