Dr. Leslie Lehmann, MD
Claim this profileBoston Children's Hospital (pediatric patients)
Studies Bone Marrow Failure Syndrome
Studies Aplastic Anemia
4 reported clinical trials
9 drugs studied
Area of expertise
1Bone Marrow Failure Syndrome
SAMD9 positive
SAMD9L positive
GATA2 positive
2Aplastic Anemia
Affiliated Hospitals
Clinical Trials Leslie Lehmann, MD is currently running
Lung Injury
for Pediatric Bone Marrow Transplant
Hematopoietic stem cell transplant (HSCT) is an effective but toxic therapy and pulmonary morbidity affects as many as 25% of children receiving transplant. Early pulmonary injury includes diffuse alveolar hemorrhage (DAH), thrombotic microangiopathy (TMA) interstitial pneumonitis (IPS) and infection, while later, bronchiolitis obliterans is a complication of chronic GVHD associated with severe morbidity and mortality. Improved diagnosis and treatment of pulmonary complications are urgently needed as survival after HSCT improves, and as HSCT is increasingly used for non-malignant disorders such as sickle cell disease. Currently, there are large and important gaps in the investigator's knowledge regarding incidence, etiology and optimal treatment of pulmonary complications. Moreover, young children unable to perform spirometry are often diagnosed late, and strategies for monitoring therapeutic response are limited. This is a prospective multi-institutional cohort study in pediatric patients undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT). Assembly of a large prospective uniformly screened cohort of children receiving HSCT, together with collection of biological samples, will be an effective strategy to identify mechanisms of lung injury, test novel diagnostic strategies for earlier diagnosis, and novel treatments to reduce morbidity and mortality from lung injury after transplant.
Recruiting1 award N/A1 criteria
Xylitol Wipes
for Bloodstream Infections in Stem Cell Transplant Patients
Bloodstream infections (BSI) caused by bacteria translocating across injured oral mucosa are a significant cause of morbidity and mortality in patients undergoing stem cell transplantation (SCT). Unfortunately, there are currently no known strategies to prevent these BSI in this vulnerable population. The investigators will conduct a randomized, double-blind, placebo-controlled trial at three institutions to evaluate the effectiveness of twice daily intraoral xylitol-wipe application on reducing BSI in pediatric SCT patients.
Recruiting0 awards Phase 2
More about Leslie Lehmann, MD
Clinical Trial Related3 years of experience running clinical trials · Led 4 trials as a Principal Investigator · 2 Active Clinical TrialsTreatments Leslie Lehmann, MD has experience with
- Fludarabine
- Alemtuzumab
- Cyclosporins
- Mycophenolate Mofetil
- Tacrolimus
- Thymoglobulin (Rabbit Anti-thymocyte Globulin; RATG)
Breakdown of trials Leslie Lehmann, MD has run
Bone Marrow Failure Syndrome
Aplastic Anemia
Dyskeratosis congenita
Spastic paraplegia
Dyskeratosis Congenita
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Leslie Lehmann, MD specialize in?
Leslie Lehmann, MD focuses on Bone Marrow Failure Syndrome and Aplastic Anemia. In particular, much of their work with Bone Marrow Failure Syndrome has involved SAMD9 positive patients, or patients who are SAMD9L positive.
Is Leslie Lehmann, MD currently recruiting for clinical trials?
Yes, Leslie Lehmann, MD is currently recruiting for 2 clinical trials in Boston Massachusetts. If you're interested in participating, you should apply.
Are there any treatments that Leslie Lehmann, MD has studied deeply?
Yes, Leslie Lehmann, MD has studied treatments such as Fludarabine, Alemtuzumab, Cyclosporins.
What is the best way to schedule an appointment with Leslie Lehmann, MD?
Apply for one of the trials that Leslie Lehmann, MD is conducting.
What is the office address of Leslie Lehmann, MD?
The office of Leslie Lehmann, MD is located at: Boston Children's Hospital (pediatric patients), Boston, Massachusetts 02115 United States. This is the address for their practice at the Boston Children's Hospital (pediatric patients).
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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