Fund in honor of Rebecca Aleck Koltun

Dr. Kristen Spencer, MD

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Rutgers Cancer Institute of New Jersey

Studies Cancer
Studies Pancreatic Cancer
14 reported clinical trials
46 drugs studied

Area of expertise

1Cancer
Kristen Spencer, MD has run 7 trials for Cancer. Some of their research focus areas include:
Stage IV
Stage III
KRAS positive
2Pancreatic Cancer
Kristen Spencer, MD has run 6 trials for Pancreatic Cancer. Some of their research focus areas include:
Stage IV
Stage III
KRAS positive

Affiliated Hospitals

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Rutgers Cancer Institute Of New Jersey
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Laura And Isaac Perlmutter Cancer Center At NYU Langone

Clinical Trials Kristen Spencer, MD is currently running

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CAR T-Cell Preparation

for Cancer

Objective: To collect information on how often a solid tumor cancer might lose the Human Leukocyte Antigen (HLA) by next generation sequencing and perform apheresis to collect and store an eligible participant's own T cells for future use to make CAR T-Cell therapy for their disease treatment. Design: This is a non-interventional, observational study to evaluate participants with solid tumors with a high risk of relapse for incurable disease. No interventional therapy will be administered on this study. Some of the information regarding the participant's tumor analysis may be beneficial to management of their disease. Participants that meet all criteria may be enrolled and leukapheresed (blood cells collected). The participant's cells will be processed and stored for potential manufacture of CAR T-cell therapy upon relapse of their cancer.
Recruiting1 award N/A3 criteria
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CA-4948 + Chemotherapy

for Pancreatic Cancer

This phase I trial tests the safety, side effects, and best dose of emavusertib (CA-4948) in combination with gemcitabine and nab-paclitaxel in treating patients with pancreatic ductal adenocarcinoma that has spread from where it first started (primary site) to other places in the body (metastatic) or cannot be removed by surgery (unresectable). CA-4948 is in a class of medications called kinase inhibitors. It works by blocking the action of abnormal proteins called interleukin-1 receptor-associated kinase 4 (IRAK4) and FMS-like tyrosine kinase 3 (FLT3) that signal cells to multiply. This may help keep cancer cells from growing. The usual approach for patients with pancreatic ductal adenocarcinoma is treatment with chemotherapy drugs gemcitabine and nab-paclitaxel. Gemcitabine is a chemotherapy drug that blocks the cells from making DNA and may kill cancer cells. Paclitaxel is in a class of medications called anti-microtubule agents. It stops cancer cells from growing and dividing and may kill them. Nab-paclitaxel is an albumin-stabilized nanoparticle formulation of paclitaxel which may have fewer side effects and work better than other forms of paclitaxel. Giving CA-4948 in combination with gemcitabine and nab-paclitaxel may shrink or stabilize metastatic or unresectable pancreatic ductal adenocarcinoma.
Recruiting1 award Phase 120 criteria

More about Kristen Spencer, MD

Clinical Trial Related3 years of experience running clinical trials · Led 14 trials as a Principal Investigator · 4 Active Clinical Trials
Treatments Kristen Spencer, MD has experience with
  • Atezolizumab
  • Panitumumab
  • Sotorasib
  • Nab-paclitaxel
  • Nivolumab
  • Olaparib

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