Jun Zhang - Houston Methodist Scholars

Dr. Jun Zhang

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Houston Methodist Hospital

Expert in Lung Cancer
Studies Non-Small Cell Lung Cancer
28 reported clinical trials
43 drugs studied

About Jun Zhang

Education:

  • Received MD from Hunan Medical University, China.

Experience:

  • Completed Internal Medicine Residency at New Hanover Medical Center, Wilmington, NC.
  • Undertook Hematology-Oncology Fellowship at Brody School of Medicine, East Carolina University.
  • Holds a faculty position at Baylor College of Medicine.
  • Program Director of the Hematology-Oncology Fellowship at Houston Methodist Hospital since 2018.
  • Focuses on thoracic oncology and head & neck cancer clinical research.

Area of expertise

1

Lung Cancer

Global Leader

Jun Zhang has run 12 trials for Lung Cancer. Some of their research focus areas include:

Stage IV
Stage III
Stage I
2

Non-Small Cell Lung Cancer

Jun Zhang has run 5 trials for Non-Small Cell Lung Cancer. Some of their research focus areas include:

PD-L1 positive
Stage III
PD-L1 negative

Affiliated Hospitals

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Houston Methodist Hospital

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Houston Methodist West Hospital

Clinical Trials Jun Zhang is currently running

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Osimertinib + Bevacizumab

for Lung Cancer

This phase III trial compares the effect of bevacizumab and osimertinib combination vs. osimertinib alone for the treatment of non-small cell lung cancer that has spread outside of the lungs (stage IIIB-IV) and has a change (mutation) in a gene called EGFR. The EGFR protein is involved in cell signaling pathways that control cell division and survival. Sometimes, mutations in the EGFR gene cause EGFR proteins to be made in higher than normal amounts on some types of cancer cells. This causes cancer cells to divide more rapidly. Osimertinib may stop the growth of tumor cells by blocking EGFR that is needed for cell growth in this type of cancer. Bevacizumab is in a class of medications called antiangiogenic agents. It works by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of tumor. Giving osimertinib with bevacizumab may control cancer for longer and help patients live longer as compared to osimertinib alone.

Recruiting

2 awards

Phase 3

31 criteria

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IBI343

for Cancer

This is a Phase Ia/Ib, multicenter, open-label, first-in-human study to evaluate the safety, tolerability, PK, and efficacy of IBI343 in participants with locally advanced unresectable or metastatic solid tumors. It is planned to be carried out in different countries or regions such as China, Australia and US. There are three parts in phase Ia. Part 1 includes dose escalation and expansion phase and part 2 is designed for dose optimization for IBI343 monotherapy. Part 3 1L G/GEJ AC and 1L PDAC cohorts will include an initial safety lead-in stage to confirm the tolerability of IBI343 in combination with chemotherapy in 1L PDAC and G/GEJ AC, followed by a randomized dose-optimization stage designed to further characterize safety, pharmacokinetics, and preliminary efficacy to inform selection of the recommended Phase 3 dose. Part 3 metabolite profiling cohort is designed to explore the payload metabolites in an advanced PDAC population.

Recruiting

1 award

Phase 1

1 criteria

More about Jun Zhang

Clinical Trial Related

6 years of experience running clinical trials · Led 28 trials as a Principal Investigator · 12 Active Clinical Trials

Treatments Jun Zhang has experience with

  • Pembrolizumab
  • Cisplatin
  • Carboplatin
  • Berzosertib
  • Gemcitabine Hydrochloride
  • Paclitaxel

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