Dr. Jeffrey S. Dome
Claim this profileChildren's National Medical Center
Expert in Cancer
Expert in Brain Tumor
67 reported clinical trials
116 drugs studied
About Jeffrey S. Dome
Education:
- Holds both an MD (Doctor of Medicine) and a PhD (Doctor of Philosophy).
Experience:
- Currently the Senior Vice President of the Center for Cancer and Blood Disorders at Children's National Hospital.
- Elected as the Continental President of North America for the International Society of Paediatric Oncology (SIOP) in March 2021.
- Chaired the 49th annual SIOP congress in Washington, D.C., in 2017.
- Has been an active member of SIOP since attending his first meeting in 2005, including serving on the SIOP Board of Directors.
Area of expertise
1Cancer
Global LeaderStage I
Stage IV
Stage II
2Brain Tumor
Global LeaderStage I
Stage II
Stage IV
Affiliated Hospitals
Clinical Trials Jeffrey S. Dome is currently running
Selumetinib vs. Chemotherapy
for Brain Cancer
This trial is comparing a new drug, selumetinib, with standard chemotherapy to treat patients with a specific type of brain tumor. The patients do not have a certain genetic mutation and are not affected by a genetic disorder. Selumetinib works by blocking enzymes needed for tumor growth, while the standard drugs kill or stop tumor cells from dividing.
Recruiting2 awards Phase 3
Inotuzumab Ozogamicin
for Acute Lymphoblastic Leukemia
This phase III trial studies whether inotuzumab ozogamicin added to post-induction chemotherapy for patients with High-Risk B-cell Acute Lymphoblastic Leukemia (B-ALL) improves outcomes. This trial also studies the outcomes of patients with mixed phenotype acute leukemia (MPAL), and B-lymphoblastic lymphoma (B-LLy) when treated with ALL therapy without inotuzumab ozogamicin. Inotuzumab ozogamicin is a monoclonal antibody, called inotuzumab, linked to a type of chemotherapy called calicheamicin. Inotuzumab attaches to cancer cells in a targeted way and delivers calicheamicin to kill them. Other drugs used in the chemotherapy regimen, such as cyclophosphamide, cytarabine, dexamethasone, doxorubicin, daunorubicin, methotrexate, leucovorin, mercaptopurine, prednisone, thioguanine, vincristine, and pegaspargase or calaspargase pegol work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. This trial will also study the outcomes of patients with mixed phenotype acute leukemia (MPAL) and disseminated B lymphoblastic lymphoma (B-LLy) when treated with high-risk ALL chemotherapy. The overall goal of this study is to understand if adding inotuzumab ozogamicin to standard of care chemotherapy maintains or improves outcomes in High Risk B-cell Acute Lymphoblastic Leukemia (HR B-ALL). The first part of the study includes the first two phases of therapy: Induction and Consolidation. This part will collect information on the leukemia, as well as the effects of the initial treatment, to classify patients into post-consolidation treatment groups. On the second part of this study, patients with HR B-ALL will receive the remainder of the chemotherapy cycles (interim maintenance I, delayed intensification, interim maintenance II, maintenance), with some patients randomized to receive inotuzumab. The patients that receive inotuzumab will not receive part of delayed intensification. Other aims of this study include investigating whether treating both males and females with the same duration of chemotherapy maintains outcomes for males who have previously been treated for an additional year compared to girls, as well as to evaluate the best ways to help patients adhere to oral chemotherapy regimens. Finally, this study will be the first to track the outcomes of subjects with disseminated B-cell Lymphoblastic Leukemia (B-LLy) or Mixed Phenotype Acute Leukemia (MPAL) when treated with B-ALL chemotherapy.
Recruiting2 awards Phase 3
More about Jeffrey S. Dome
Clinical Trial Related8 years of experience running clinical trials · Led 67 trials as a Principal Investigator · 21 Active Clinical TrialsTreatments Jeffrey S. Dome has experience with
- Cyclophosphamide
- Radiation Therapy
- Nivolumab
- Etoposide
- Vincristine Sulfate
- Laboratory Biomarker Analysis
Breakdown of trials Jeffrey S. Dome has run
Cancer
Brain Tumor
Neuroblastoma
Brain Cancer
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Jeffrey S. Dome specialize in?
Jeffrey S. Dome focuses on Cancer and Brain Tumor. In particular, much of their work with Cancer has involved Stage I patients, or patients who are Stage IV.
Is Jeffrey S. Dome currently recruiting for clinical trials?
Yes, Jeffrey S. Dome is currently recruiting for 21 clinical trials in Washington District of Columbia. If you're interested in participating, you should apply.
Are there any treatments that Jeffrey S. Dome has studied deeply?
Yes, Jeffrey S. Dome has studied treatments such as Cyclophosphamide, Radiation Therapy, Nivolumab.
What is the best way to schedule an appointment with Jeffrey S. Dome?
Apply for one of the trials that Jeffrey S. Dome is conducting.
What is the office address of Jeffrey S. Dome?
The office of Jeffrey S. Dome is located at: Children's National Medical Center, Washington, District of Columbia 20010 United States. This is the address for their practice at the Children's National Medical Center.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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