Dr. Emil Coccaro, Dr

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Ohio State University Harding Hospital

Studies Impulse Control Disorders
Studies Intermittent Explosive Disorder
4 reported clinical trials
12 drugs studied

Affiliated Hospitals

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Ohio State University Harding Hospital
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The Ohio State University Wexner Medical Center

Clinical Trials Emil Coccaro, Dr is currently running

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Alcohol Effects on Brain Activity During Intoxication

for undefined

Alcohol intoxication is responsible for a large proportion of violent crime/assault and personal injury in our society. While a number of variables have been associated with alcohol-related aggression, high trait aggression and impaired executive function have been identified as key factors. Both Alcohol Use Disorder (AUD) and Impulsive Aggression behavior (AGG) are related to impaired social-emotional information processing (SEIP) whereby social threat cues, especially ones that are ambiguous in nature, lead to hostile attribution and negative emotional response to the "other" and, then, aggression against the "other". Thus, understanding the underlying neuroscience of SEIP under the influence of alcohol will be critical to identifying targets for intervention to reduce alcohol-related aggressive behavior. In addition to potential pharmacologic and cognitive-behavioral based interventions, such interventions may also involve the rehabilitation of aberrant neuronal circuits underlying social cognitive function through neuroplasticity-based remediation exercises. This study is designed to see how brain activation of cortico-limbic circuits involving social-emotional information processing, analyzed by fMRI Imaging, are impacted by alcohol administration in those with and without aggressive disorders and with and without alcohol use disorder.
Recruiting0 awards Phase 223 criteria
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Nitrous Oxide

for Aggression

This trial tests if inhaling nitrous oxide can help normalize brain function in people with impulsive aggression. Participants with and without aggressive tendencies will inhale the gas and undergo brain scans to see if it improves their brain activity. The goal is to find a potential treatment for those with Intermittent Explosive Disorder. Nitrous oxide has been shown to reduce involuntary movements in cerebral palsy patients, indicating its potential to affect brain function.
Recruiting0 awards Phase 211 criteria

More about Emil Coccaro, Dr

Clinical Trial Related4 years of experience running clinical trials · Led 4 trials as a Principal Investigator · 2 Active Clinical Trials
Treatments Emil Coccaro, Dr has experience with
  • Nitrous Oxide
  • Room Air
  • Cognitive-behavioral Based Interventions
  • Impaired Social-emotional Information Processing
  • Intervention To Reduce Alcohol-related Aggressive Behavior
  • Neural Correlates During Alcohol Intoxication

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