Dr. Edith I. Tzeng, MD

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VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA

Studies Intermittent Claudication
Studies Heart Attack
3 reported clinical trials
7 drugs studied

Affiliated Hospitals

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VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA
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VA Pittsburgh Healthcare

Clinical Trials Edith I. Tzeng, MD is currently running

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Metformin

for Intermittent Claudication

Peripheral arterial disease (PAD) affects over 20% of aged adults and is very common among Veterans due significant tobacco use. PAD is due to the progressive blockage of peripheral arteries, predominantly to the legs, and results in intermittent claudication (IC) or recurrent muscle pain with activity secondary to insufficient blood supply. Those with PAD and IC experience a progressive decline in walking and poor quality of life. There is no effective medical treatment for PAD and IC. Metformin is a safe and effective treatment for Type 2 diabetes but it can also reduce inflammation, oxidative stress, and improve energy requirements as well as improve blood flow to the legs. Therefore, the investigators will test the ability of Metformin to improve overall functional status, reduce PAD progression, and reduce systemic inflammation in Veterans suffering from PAD and IC in a randomized, placebo controlled trial: Metformin BenefIts Lower Extremities with Intermittent Claudication (MOBILE IC) Trial. The success of this trial may identify a safe and effective treatment for PAD and IC.
Recruiting1 award Phase 36 criteria

More about Edith I. Tzeng, MD

Clinical Trial Related10 years of experience running clinical trials · Led 3 trials as a Principal Investigator · 1 Active Clinical Trial
Treatments Edith I. Tzeng, MD has experience with
  • Metformin ER
  • Placebo
  • Blood Transfusion
  • Carotid Endarterectomy (CEA)
  • Carotid Stenting (CAS)
  • Intensive Medical Management - No CAS
Breakdown of trials Edith I. Tzeng, MD has run
Intermittent Claudication
Heart Attack
Acute Kidney Injury
Myocardial Infarction or Heart Attack
Coronary Artery Bypass

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