Dr. Cristina Rodriguez, MD – Seattle ...

Dr. Cristina P Rodriguez

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Seattle Cancer Care Alliance / University of Washington

Studies Squamous Cell Carcinoma
Studies Head and Neck Cancers
7 reported clinical trials
16 drugs studied

Area of expertise

1

Squamous Cell Carcinoma

Cristina P Rodriguez has run 4 trials for Squamous Cell Carcinoma. Some of their research focus areas include:

Stage IV
p16 negative
PD-L1 positive
2

Head And Neck Cancers

Cristina P Rodriguez has run 3 trials for Head and Neck Cancers. Some of their research focus areas include:

Stage IV
PD-L1 positive
p16 positive

Affiliated Hospitals

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Seattle Cancer Care Alliance / University Of Washington

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Fred Hutchinson Cancer Center / Seattle Cancer Care Alliance / University Of Washington

Clinical Trials Cristina P Rodriguez is currently running

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Chemotherapy + Radiation Therapy

for Head and Neck Cancer

This phase II/III trial studies how well radiation therapy works when given together with cisplatin, docetaxel, cetuximab, and/or atezolizumab after surgery in treating patients with high-risk stage III-IV head and neck cancer the begins in the thin, flat cells (squamous cell). Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in chemotherapy, such as cisplatin and docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Cetuximab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. The purpose of this study is to compare the usual treatment (radiation therapy with cisplatin chemotherapy) to using radiation therapy with docetaxel and cetuximab chemotherapy, and using the usual treatment plus an immunotherapy drug, atezolizumab.

Recruiting

1 award

Phase 2 & 3

21 criteria

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Trastuzumab Emtansine

for Salivary Gland Cancer

This phase II trial compares the effect of usual treatment of docetaxel chemotherapy plus trastuzumab, to ado-emtansine (T-DM1) in patients with HER2-postive salivary gland cancer that has come back (recurrent), that has spread from where it first started (primary site) to other places in the body, or cannot be removed by surgery (unresectable). This trial is also testing how well trastuzumab deruxtecan works in treating patients with HER2-low recurrent or metastatic salivary gland cancer. Trastuzumab is a form of targeted therapy because it works by attaching itself to specific molecules (receptors) on the surface of cancer cells, known as HER2 receptors. When trastuzumab attaches to HER2 receptors, the signals that tell the cells to grow are blocked and the cancer cell may be marked for destruction by body's immune system. Trastuzumab emtansine contains trastuzumab, linked to a chemotherapy drug called emtansine. Trastuzumab attaches to HER2 positive cancer cells in a targeted way and delivers emtansine to kill them. Trastuzumab deruxtecan is a monoclonal antibody called traztuzumab, linked to a chemotherapy drug called deruxtecan. Trastuzumab is a form of targeted therapy because it attaches to specific molecules (receptors) on the surface of cancer cells, known as HER2 receptors and delivers deruxtecan to kill them. Docetaxel is in a class of medications called taxanes. It stops cancer cells from growing and dividing and may kill them. Trastuzumab emtansine may work better compared to usual treatment of chemotherapy with docetaxel and trastuzumab or trastuzumab deruxtecan in treating patients with recurrent, metastatic or unresectable salivary gland cancer.

Recruiting

1 award

Phase 2

More about Cristina P Rodriguez

Clinical Trial Related

7 years of experience running clinical trials · Led 7 trials as a Principal Investigator · 2 Active Clinical Trials

Treatments Cristina P Rodriguez has experience with

  • Cisplatin
  • Nivolumab
  • Pembrolizumab
  • Docetaxel
  • IK-175
  • Carboplatin

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