Claudia R. Morris | Faculty | People ...

Dr. Claudia Morris, MD

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Children's Healthcare of Atlanta, Emory University

Studies Sickle Cell Disease
Studies Coronavirus
7 reported clinical trials
11 drugs studied

Area of expertise

1Sickle Cell Disease
Claudia Morris, MD has run 2 trials for Sickle Cell Disease. Some of their research focus areas include:
Hb-SS positive
Sβᴼ-thalassemia positive
2Coronavirus
Claudia Morris, MD has run 1 trial for Coronavirus.

Affiliated Hospitals

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Children's Healthcare Of Atlanta/Emory University
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Emory University/Childrens Healthcare Of Atlanta

Clinical Trials Claudia Morris, MD is currently running

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Arginine Therapy

for COVID-19

This study aims to investigate if receiving doses of arginine (a protein in the body) will improve mitochondria function in children with COVID-19. The study will be performed at the Children's Healthcare of Atlanta, Arthur M. Blank Hospital. Patients will be randomized to receive one of three doses of arginine three times a day for five days or at discharge whichever comes first.
Recruiting1 award Phase 22 criteria
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Age-Based Seizure Protocol

for Pediatric Seizures

The Pediatric Dose Optimization for Seizures in Emergency Medical Services (PediDOSE) study is designed to improve how paramedics treat seizures in children on ambulances. Seizures are one of the most common reasons why people call an ambulance for a child, and paramedics typically administer midazolam to stop the seizure. One-third of children with active seizures on ambulances arrive at emergency departments still seizing. Prior research suggests that seizures on ambulances continue due to under-dosing and delayed delivery of medication. Under-dosing happens when calculation errors occur, and delayed medication delivery occurs due to the time required for dose calculation and placement of an intravenous line to give the medication. Seizures stop quickly when standardized medication doses are given as a muscular injection or a nasal spray. This research has primarily been done in adults, and evidence is needed to determine if this is effective and safe in children. PediDOSE optimizes how paramedics choose the midazolam dose by eliminating calculations and making the dose age-based. This study involves changing the seizure treatment protocols for ambulance services in 20 different cities, in a staggered and randomly-assigned manner. One aim of PediDOSE is to determine if using age to select one of four standardized doses of midazolam and giving it as a muscular injection or nasal spray is more effective than the current calculation-based method, as measured by the number of children arriving at emergency departments still seizing. The investigators believe that a standardized seizure protocol with age-based doses is more effective than current practice. Another aim of PediDOSE is to determine if a standardized seizure protocol with age-based doses is just as safe as current practice, since either ongoing seizures or receiving too much midazolam can interfere with breathing. The investigators believe that a standardized seizure protocol with age-based doses is just as safe as current practice, since the seizures may stop faster and these doses are safely used in children in other healthcare settings. If this study demonstrates that standardized, age-based midazolam dosing is equally safe and more effective in comparison to current practice, the potential impact of this study is a shift in the treatment of pediatric seizures that can be easily implemented in ambulance services across the United States and in other parts of the world.
Recruiting2 awards Phase 33 criteria

More about Claudia Morris, MD

Clinical Trial Related5 years of experience running clinical trials · Led 7 trials as a Principal Investigator · 3 Active Clinical Trials
Treatments Claudia Morris, MD has experience with
  • Arginine Hydrochloride
  • Arginine
  • Azithromycin
  • Placebo
  • Conventional Seizure Protocol
  • Standardized Seizure Protocol

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