Aparkishor P Ganti, MBBS | Nebraska ...

Dr. Apar K. Ganti

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University of Nebraska Medical Center

Studies Lung Cancer
Studies Non-Small Cell Lung Cancer
8 reported clinical trials
15 drugs studied

Area of expertise

1

Lung Cancer

Apar K. Ganti has run 6 trials for Lung Cancer. Some of their research focus areas include:

Stage IV
Stage I
Stage II
2

Non-Small Cell Lung Cancer

Apar K. Ganti has run 3 trials for Non-Small Cell Lung Cancer. Some of their research focus areas include:

Stage III
Stage IV
Stage II

Affiliated Hospitals

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University Of Nebraska Medical Center

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Nebraska Medicine-Village Pointe

Clinical Trials Apar K. Ganti is currently running

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TAB004 + Toripalimab

for Solid Cancers

The primary objective is to assess the safety and tolerability of TAB004 as monotherapy and in combination with toripalimab in subjects with selected advanced solid malignancies, including lymphoma, and to evaluate the recommended Phase 2 dose. The secondary objectives are to: 1) describe the pharmacokinetic (PK) profile of TAB004 monotherapy and in combination with toripalimab and to describe the PK profile of toripalimab when administered with TAB004, 2) evaluate antitumor activity of TAB004 monotherapy and in combination with toripalimab; and 3) determine the immunogenicity of TAB004 monotherapy and in combination with toripalimab and to determine the immunogenicity of toripalimab when administered with TAB004. The exploratory objectives are to: 1) evaluate pharmacodynamic effects of TAB004 on its target receptor BTLA, as well as effects on the immune system; 2) evaluate biomarkers that may correlate with activity of TAB004 as monotherapy and in combination with toripalimab; 3) evaluate the utility of BTLA ligand, herpesvirus-entry mediator (HVEM), and additional exploratory biomarkers that could aid in selection of appropriate subjects for TAB004 monotherapy and in combination with toripalimab.

Recruiting

1 award

Phase 1

10 criteria

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Immunotherapy + Chemotherapy

for Non-Small Cell Lung Cancer

This phase III ALCHEMIST treatment trial tests the addition of pembrolizumab to usual chemotherapy for the treatment of stage IIA, IIB, IIIA or IIIB non-small cell lung cancer that has been removed by surgery. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as cisplatin, pemetrexed, carboplatin, gemcitabine hydrochloride, and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving pembrolizumab with usual chemotherapy may help increase survival times in patients with stage IIA, IIB, IIIA or IIIB non-small cell lung cancer.

Recruiting

2 awards

Phase 3

27 criteria

More about Apar K. Ganti

Clinical Trial Related

10 years of experience running clinical trials · Led 8 trials as a Principal Investigator · 3 Active Clinical Trials

Treatments Apar K. Ganti has experience with

  • Pembrolizumab
  • Carboplatin
  • Crizotinib
  • Capecitabine
  • Docetaxel
  • Cisplatin

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