Al B. Benson III, MD | Northwestern ...

Dr. Al B. Benson

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Northwestern University

Studies Rectal Cancer
Studies Colon Cancer
10 reported clinical trials
22 drugs studied

Area of expertise

1

Rectal Cancer

Al B. Benson has run 2 trials for Rectal Cancer. Some of their research focus areas include:

Stage III
Stage IV
BRAF negative
2

Colon Cancer

Al B. Benson has run 2 trials for Colon Cancer. Some of their research focus areas include:

Stage III
Stage IV
BRAF negative

Affiliated Hospitals

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Northwestern University

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Northwestern Medicine Lake Forest Hospital

Clinical Trials Al B. Benson is currently running

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Preoperative Chemotherapy + Surgery

for Sarcoma

This is a multicenter, randomized, open label phase lll trial to assess whether preoperative chemotherapy, as an adjunct to curative-intent surgery, improves the prognosis of high risk DDLPS (dedifferentiated Liposarcoma) and LMS (Leiomyosarcoma) patients as measured by disease free survival. After confirmation of eligibility criteria, patients will be randomized to either the standard arm or experimental arm.

Recruiting

2 awards

Phase 3

5 criteria

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Radioactive Drug vs Everolimus

for Neuroendocrine Cancer

This phase II trial compares the effect of retreatment with 177Lu-DOTATATE peptide receptor radionuclide therapy (PRRT) to the usual approach of treatment with everolimus, sunitinib, or cabozantinib in patients who have previously received 177Lu-DOTATATE for gastroenteropancreatic neuroendocrine tumor (GEPNET) that has spread from where it first started (primary site) to other places in the body (metastatic) and that cannot be removed by surgery (unresectable). PRRT is a type of radiation therapy for which a radioactive chemical is linked to a peptide (small protein) that targets tumor cells. When this radioactive peptide is injected into the body, it binds to a specific receptor found on some tumor cells. The radioactive peptide builds up in these cells and helps kill the tumor cells without harming normal cells. In this trial 177Lu-DOTATATE is used for PRRT. 177Lu-DOTATATE PRRT may increase the length of time until worsening of the GEPNET compared to the usual approach. Everolimus is in a class of medications called kinase inhibitors. It is also a type of angiogenesis inhibitor. Everolimus works by stopping tumor cells from reproducing and by decreasing blood supply to the tumor cells. Sunitinib and cabozantinib, block certain proteins, which may help keep tumor cells from growing. They may also prevent the growth of new blood vessels that tumors need to grow. Sunitinib malate is a type of tyrosine kinase inhibitor and a type of antiangiogenesis agent. Retreating with 177Lu-DOTATATE may work better than everolimus, sunitinib or cabozantinib in shrinking or stabilizing tumors in patients with metastatic and unresectable GEPNET who were previously treated with 177Lu-DOTATATE.

Recruiting

1 award

Phase 2

More about Al B. Benson

Clinical Trial Related

2 years of experience running clinical trials · Led 10 trials as a Principal Investigator · 2 Active Clinical Trials

Treatments Al B. Benson has experience with

  • Lutetium Lu 177 Dotatate
  • Oxaliplatin
  • Preoperative Chemotherapy
  • Surgery
  • Trastuzumab
  • Pertuzumab

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