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Trial Status
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61 Amyotrophic Lateral Sclerosis Trials Near You
Power is an online platform that helps thousands of Amyotrophic Lateral Sclerosis patients discover FDA-reviewed trials every day. Every trial we feature meets safety and ethical standards, giving patients an easy way to discover promising new treatments in the research stage.
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Key Eligibility Criteria
3 Participants Needed
Personalized Treatments for ALS
Trial Details
Key Eligibility Criteria
50 Participants Needed
Retinal Imaging for Neurodegenerative Disease
Trial Details
Key Eligibility Criteria
2000 Participants Needed
Neurosleeve for Arm Weakness/Paralysis
Trial Details
Key Eligibility Criteria
20 Participants Needed
VGL101 for Leukoencephalopathy
Trial Details
Key Eligibility Criteria
20 Participants Needed
Mechanical Insufflation for ALS
Trial Details
Key Eligibility Criteria
20 Participants Needed
Behavioral Nudge for Genetic Predisposition
Trial Details
Key Eligibility Criteria
1000 Participants Needed
BrainGate2 Neural Interface for Quadriplegia
Trial Details
Key Eligibility Criteria
27 Participants Needed
RAPA-501 Therapy for ALS
Trial Details
Key Eligibility Criteria
41 Participants Needed
Antisense Oligonucleotide for ALS
Trial Details
Key Eligibility Criteria
1 Participants Needed
Dalfampridine for ALS
Trial Details
Key Eligibility Criteria
35 Participants Needed
BCI Technology for Paralysis
Trial Details
Key Eligibility Criteria
6 Participants Needed
Regulatory T Cells for ALS
Trial Details
Key Eligibility Criteria
66 Participants Needed
SCAP and Hand Exercises for ALS
Trial Details
Key Eligibility Criteria
32 Participants Needed
TJ-68 for ALS
Trial Details
Key Eligibility Criteria
11 Participants Needed
Brain Imaging Tracer for Neurodegenerative Disease
Trial Details
Key Eligibility Criteria
40 Participants Needed
Yogic Breathing Exercises for ALS
Trial Details
Key Eligibility Criteria
30 Participants Needed
Stem Cell Therapy for Neurological Disorders
Trial Details
Key Eligibility Criteria
500 Participants Needed
Stem Cell Therapy for ALS
Trial Details
Key Eligibility Criteria
75 Participants Needed
ARGX-119 for ALS
Trial Details
Key Eligibility Criteria
60 Participants Needed
Why Other Patients Applied
"I have dealt with voice and vocal fold issues related to paralysis for over 12 years. This problem has negatively impacted virtually every facet of my life. I am an otherwise healthy 48 year old married father of 3 living. My youngest daughter is 12 and has never heard my real voice. I am now having breathing issues related to the paralysis as well as trouble swallowing some liquids. In my research I have seen some recent trials focused on helping people like me."
"As a healthy volunteer, I like to participate in as many trials as I'm able to. It's a good way to help research and earn money."
"My orthopedist recommended a half replacement of my right knee. I have had both hips replaced. Currently have arthritis in knee, shoulder, and thumb. I want to avoid surgery, and I'm open-minded about trying a trial before using surgery as a last resort."
"I've been struggling with ADHD and anxiety since I was 9 years old. I'm currently 30. I really don't like how numb the medications make me feel. And especially now, that I've lost my grandma and my aunt 8 days apart, my anxiety has been even worse. So I'm trying to find something new."
"I have dealt with voice and vocal fold issues related to paralysis for over 12 years. This problem has negatively impacted virtually every facet of my life. I am an otherwise healthy 48 year old married father of 3 living. My youngest daughter is 12 and has never heard my real voice. I am now having breathing issues related to the paralysis as well as trouble swallowing some liquids. In my research I have seen some recent trials focused on helping people like me."
Darifenacin for ALS
Trial Details
Key Eligibility Criteria
30 Participants Needed
VRG50635 for ALS
Trial Details
Key Eligibility Criteria
54 Participants Needed
Prosetin for ALS
Trial Details
Key Eligibility Criteria
72 Participants Needed
Probiotics for ALS
Trial Details
Key Eligibility Criteria
150 Participants Needed
Brain-Computer Interface for Paralysis
Trial Details
Key Eligibility Criteria
2 Participants Needed
SPG302 for ALS
Trial Details
Key Eligibility Criteria
112 Participants Needed
DNL343 for ALS
Trial Details
Key Eligibility Criteria
240 Participants Needed
MyoRegulator® for ALS
Trial Details
Key Eligibility Criteria
5 Participants Needed
Baricitinib for Alzheimer's & ALS
Trial Details
Key Eligibility Criteria
20 Participants Needed
BrainGate2 System for Quadriplegia
Trial Details
Key Eligibility Criteria
2 Participants Needed
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We started Power when my dad was diagnosed with multiple myeloma, and I struggled to help him access the latest immunotherapy. Hopefully Power makes it simpler for you to explore promising new treatments, during what is probably a difficult time.
Frequently Asked Questions
How much do Amyotrophic Lateral Sclerosis clinical trials pay?
Each trial will compensate patients a different amount, but $50-100 for each visit is a fairly common range for Phase 2–4 trials (Phase 1 trials often pay substantially more). Further, most trials will cover the costs of a travel to-and-from the clinic.
How do Amyotrophic Lateral Sclerosis clinical trials work?
After a researcher reviews your profile, they may choose to invite you in to a screening appointment, where they'll determine if you meet 100% of the eligibility requirements. If you do, you'll be sorted into one of the treatment groups, and receive your study drug. For some trials, there is a chance you'll receive a placebo. Across Amyotrophic Lateral Sclerosis trials 30% of clinical trials have a placebo. Typically, you'll be required to check-in with the clinic every month or so. The average trial length for Amyotrophic Lateral Sclerosis is 12 months.
How do I participate in a study as a "healthy volunteer"?
Not all studies recruit healthy volunteers: usually, Phase 1 studies do. Participating as a healthy volunteer means you will go to a research facility several times over a few days or weeks to receive a dose of either the test treatment or a "placebo," which is a harmless substance that helps researchers compare results. You will have routine tests during these visits, and you'll be compensated for your time and travel, with the number of appointments and details varying by study.
What does the "phase" of a clinical trial mean?
The phase of a trial reveals what stage the drug is in to get approval for a specific condition. Phase 1 trials are the trials to collect safety data in humans. Phase 2 trials are those where the drug has some data showing safety in humans, but where further human data is needed on drug effectiveness. Phase 3 trials are in the final step before approval. The drug already has data showing both safety and effectiveness. As a general rule, Phase 3 trials are more promising than Phase 2, and Phase 2 trials are more promising than phase 1.
Do I need to be insured to participate in a Amyotrophic Lateral Sclerosis medical study?
Clinical trials are almost always free to participants, and so do not require insurance. The only exception here are trials focused on cancer, because only a small part of the typical treatment plan is actually experimental. For these cancer trials, participants typically need insurance to cover all the non-experimental components.
What are the newest Amyotrophic Lateral Sclerosis clinical trials?
Most recently, we added Speech Perception for ALS, XT-150 for ALS and Brain-Computer Interface for Paralysis to the Power online platform.
Are there any promising cures for ALS?
There is still no one-shot “cure” for ALS, but several newer drugs—riluzole, edaravone, AMX0035, and the gene-specific therapy tofersen—can modestly slow the disease, and dozens of gene, antisense, immune-modulating and stem-cell treatments are now in late-stage clinical trials. Specialists therefore view ALS care as a rapidly evolving field: staying connected to an ALS center, asking about genetic testing, and monitoring clinical-trial options offer the best chance to benefit from these emerging therapies while comprehensive supportive care maximizes quality of life today.
What is the longest lifespan after ALS diagnosis?
Most people with ALS live 2–5 years, but about 5–10 % are alive at 10 years and fewer than 1 % reach 20 years—usually those who are younger, have a slow limb-onset form, and/or use long-term ventilatory support. The longest well-documented survivor was physicist Stephen Hawking, who lived roughly 55 years after symptom onset, showing that while such extreme longevity is possible, it is an extraordinary outlier rather than the norm.
Can you still get hard with ALS?
ALS usually doesn’t damage the automatic nerves that create an erection, so many men can still “get hard.” If weakness, fatigue, mood issues or medicines make erections unreliable, standard treatments like Viagra-type pills, vacuum pumps, position changes or counselling often help—so bring any problems up with your neurologist or a urologist early.
What are the 7 stages of ALS?
Doctors don’t follow one standard “7-stage” chart for ALS; most use the King’s system (one body region affected → two → three → need for a feeding tube → need for breathing support → death) or the Milano-Torino (MiToS) system, which grades loss of independence in 1, 2, 3, or 4 key functions before death. The public 7-step list you may see online (symptom onset, diagnosis, independent phase, assisted independence, moderate loss, advanced loss, end-of-life) is simply a lay summary of these milestones. Ask your neurologist which staging scale they use so you can match care plans, equipment, and treatments to your current stage.
What is the best hospital for ALS?
There isn’t one universally “best” hospital for ALS; the goal is to be seen at an ALS Association-Certified Treatment Center of Excellence or similar multidisciplinary clinic, where neurologists, respiratory, rehab, nutrition and social-work specialists collaborate—an approach shown to prolong survival. Use the ALS Association (als.org/clinics) or MDA clinic finder to locate the nearest accredited program, then weigh travel distance, insurance coverage and access to clinical trials; highly regarded examples include Mass General’s Healey Center (MA), Johns Hopkins (MD), Mayo Clinic (MN/FL), Northwestern’s Les Turner Center (IL), Cedars-Sinai and UCSF (CA).
What is the new name for ALS?
There is no officially adopted “new” name—amyotrophic lateral sclerosis (ALS) is still the formal medical term used in disease classifications worldwide. People may hear it called “motor neurone/neuron disease (MND)” in the UK and other countries or “Lou Gehrig’s disease” in North America, but these are regional synonyms rather than a recent name change.
Who is doing research on ALS?
ALS research is a worldwide team effort: leading university clinics (e.g., Johns Hopkins, Mass General/Harvard, Mayo Clinic, University of Sheffield), large research networks such as NEALS, Project MinE, Answer ALS and Target ALS, government funders (NIH, CDC, European JPND), patient-driven nonprofits (ALS Association, ALS TDI) and biotech/pharma companies like Biogen, Amylyx and BrainStorm all run studies. To see exactly who is doing what and how to join in, visit the NEALS Trial Finder or ClinicalTrials.gov, or enroll in the CDC National ALS Registry, which sends research invitations to registered patients.
Does walking help with ALS?
Gentle, short-distance walking can help people with ALS keep their joints moving, maintain endurance, and feel better emotionally, but it will not stop the disease itself. The key is to walk at a pace that does not leave you wiped out after 30 minutes, use braces or a helper to prevent falls, and adjust or switch to seated or pool exercises as weakness advances under the guidance of your neurologist or physical therapist.
Can you recover from amyotrophic lateral sclerosis?
Today there is no way to “recover” from ALS because once the motor nerves die they cannot be rebuilt; the goal of treatment is to slow the disease and manage symptoms. Medicines such as riluzole, edaravone, the new combination pill AMX0035, and the gene-targeted drug tofersen (for certain inherited cases) plus coordinated breathing, nutrition and physical therapy can extend survival and preserve independence for months to years, while dozens of clinical trials continue to search for a true cure.
Does IVIg help ALS?
Current research shows that IVIg does not meaningfully slow down or improve ALS; at best, a few small studies saw short-lived effects that disappeared within weeks and could not be reproduced. Because of this, expert guidelines advise against using IVIg for ALS outside of clinical trials—discuss other FDA-approved options (riluzole, edaravone) and participation in research studies with your neurologist instead.