Veterans Affairs Medical Center - Dayton

Summary

Veterans Affairs Medical Center - Dayton is a medical facility located in Dayton, Ohio. This center is recognized for care of Lung Cancer, Breast Cancer, Lymphoma, Leukemia, Squamous Cell Carcinoma and other specialties. Veterans Affairs Medical Center - Dayton is involved with conducting 221 clinical trials across 200 conditions. There are 5 research doctors associated with this hospital, such as Albert S. Malcolm, Alyssa C. McManamon, Shannon Miller, MD, and Jeffrey Travers, MD.

Top PIs

Clinical Trials running at Veterans Affairs Medical Center - Dayton

Actinic Keratosis

Multiple Myeloma

Opiate Dependence

Opioid Use Disorder

Cardiovascular Disease

Mild Cognitive Impairment

Cognitive Impairment

Dementia

Imipramine

Photodynamic Therapy

Topical Imipramine

for Actinic Keratosis

The purpose of this study is to test the use of topical imipramine in combination with topical photodynamic therapy's (PDT) effect on the effectiveness and pain immunosuppression following treatment. PDT is a commonly used treatment in dermatology for patients who have many pre-cancers (actinic keratosis or "AK") on their skin. These are both FDA-approved medications, but this study is evaluating their use in combination, which has not been evaluated in the past. The investigators have been doing studies using mice that suggest imipramine might reduce immune system suppression by PDT thus allowing it to work better. Subjects whose provider has decided that they may benefit from PDT to treat their skin due to many AK precancerous lesions will be recruited for this study. Please note that the PDT itself is not experimental, only the imipramine treatment to the skin. There is a separate informed consent for the PDT.

Recruiting

1 award

Phase 2

3 criteria

Fractionated Laser Resurfacing

for Actinic Keratosis and Skin Cancer Prevention

This study is following up on previous studies that have demonstrated that geriatric subjects respond different to ultraviolet B (UVB) light than young subjects. The treatment of geriatric skin with dermal rejuvenation therapies (dermabrasion, fractionated laser resurfacing) restores the appropriate UVB response. Ongoing studies have tested the ability of fractionated laser resurfacing (FLR) to assess how long this wounding effect lasts-and have found that this appears to be a durable response which lasts for at least two years. The findings that FLR protects geriatric skin at two years is the impetus for this study. This study is an interventional study to assess if FLR treatment of one forearm of geriatric subjects with multiple actinic keratosis will result in the short-term removal of actinic keratosis, and the long-term decrease in levels of future actinic keratosis and other non-melanoma skin cancers in comparison to the untreated arm. Study length and visit: The first part of the study is completed in 1 day then there are follow up visits at 90 days and every 6 months for 5 years.

Recruiting

1 award

N/A

6 criteria