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St. Boniface General Hospital
Claim this profileWINNIPEG, Manitoba R2H 2A6
Global Leader in Heart Failure
Global Leader in Heart Attack
Conducts research for Cardiovascular Disease
Conducts research for Stroke
Conducts research for Cardiac Surgery
147 reported clinical trials
14 medical researchers
Summary
St. Boniface General Hospital is a medical facility located in WINNIPEG, Manitoba. This center is recognized for care of Heart Failure, Heart Attack, Cardiovascular Disease, Stroke, Cardiac Surgery and other specialties. St. Boniface General Hospital is involved with conducting 147 clinical trials across 235 conditions. There are 14 research doctors associated with this hospital, such as Ashish B. Shah, M.D., Ryan Zarychanski, MD, Thang Nguyen, MD, and Michael Yamashita, MD.Top PIs
Ashish B. Shah, M.D.Vanderbilt University Medical Center5 years of reported clinical research
Studies Brain Tumor
Studies Ankle Arthritis
11 reported clinical trials
14 drugs studied
Ryan Zarychanski, MDSt. Boniface Hospital3 years of reported clinical research
Studies Gastrointestinal Bleeding
Studies Upper GI Bleed
5 reported clinical trials
65 drugs studied
Thang Nguyen, MDSt. Boniface Hospital6 years of reported clinical research
Studies Breast Cancer
Studies Cardiovascular Disease
2 reported clinical trials
3 drugs studied
Michael Yamashita, MDUniversity of Manitoba7 years of reported clinical research
Studies Thoracic Aortic Disease
Studies Bleeding
2 reported clinical trials
3 drugs studied
Clinical Trials running at St. Boniface General Hospital
Heart Failure
Heart Attack
Cancer
Cardiotoxicity
Coronary Artery Disease
Heart Disease
Malnutrition
Staphylococcus aureus Infections
Staph Bacteremia
Bleeding
Stopping Heart Medications
for Cancer Survivors
Cancer therapy-related cardiac dysfunction (CTRCD) is when the heart's ability to pump oxygenated blood to the body is compromised. It is a side effect of cancer therapy which can occur as commonly as in 1 in 5 patients. When this occurs, heart failure medications are started to protect the heart from progressing to heart failure. With early detection and treatment, heart function recovers to normal in \>80% of patients. Unfortunately, heart failure medications are associated with an undesirable long-term pill burden, financial costs, and side-effects (e.g., dizziness and fatigue). As a result, cancer survivors frequently ask if they can safely stop their heart failure medications once their heart function has returned to normal. Currently there is no scientific evidence in this area of Cardio-Oncology. To address this knowledge gap, the investigators have designed a randomized control trial to assess the safety of stopping heart failure medication in patients with CTRCD and recovered heart function. The investigators will enrol patients who have completed their cancer therapy and are on heart medications for their CTRCD, which has now normalized. The investigators will randomize patients with no other reasons to continue heart failure medications (e.g., kidney disease) to continuing or stopping their heart medications safely. All patients will undergo a cardiac MRI at baseline, 1 and 5 years with safety assessments at 6-8 weeks, 6 months and 3 and 5 years. The investigators will determine if stopping medications is non-inferior to continuing medications by counting the numbers of patients who develop heart dysfunction by 1 year in each group.
Recruiting3 awards Phase 4
Omecamtiv Mecarbil
for Heart Failure
The purpose of this study is to find out if the investigational drug called omecamtiv mecarbil can reduce the risk of the effects of heart failure, like hospitalization, transplantation, or death in patients with heart failure and severely reduced ejection fraction.
Recruiting1 award Phase 310 criteria
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Frequently asked questions
What kind of research happens at St. Boniface General Hospital?
St. Boniface General Hospital is a medical facility located in WINNIPEG, Manitoba. This center is recognized for care of Heart Failure, Heart Attack, Cardiovascular Disease, Stroke, Cardiac Surgery and other specialties. St. Boniface General Hospital is involved with conducting 147 clinical trials across 235 conditions. There are 14 research doctors associated with this hospital, such as Ashish B. Shah, M.D., Ryan Zarychanski, MD, Thang Nguyen, MD, and Michael Yamashita, MD.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.