Orlando Clinical Research Center

Summary

Orlando Clinical Research Center is a medical facility located in Orlando, Florida. This center is recognized for care of Liver disease, Kidney Failure, Renal Disease, Healthy Subjects, Chronic Renal Failure and other specialties. Orlando Clinical Research Center is involved with conducting 271 clinical trials across 155 conditions. There are 1 research doctors associated with this hospital, such as Thomas C Marbury.

Top PIs

Clinical Trials running at Orlando Clinical Research Center

Liver disease

Healthy Subjects

Kidney Failure

Renal Disease

Breast Cancer

Liver Dysfunction

Hepatic Insufficiency

Schizophrenia

Breast cancer

Bacterial Infection

Palovarotene

for Liver Disease

The main aim of this study is to understand how moderate and severe liver impairment (based on the Child-Pugh classification) affects the body's processing of a single dose of 10 mg maximum of palovarotene, compared to healthy participants with normal liver function. The study will also assess the safety and tolerability of the single dose of palovarotene. Participants will be enrolled in stages and divided into three groups based on their liver function: * Group 1: Healthy participants with normal liver function * Group 2: Participants with moderate liver impairment * Group 3: Participants with severe liver impairment (only enrolled if Group 2 results are safe and acceptable) Blood samples will be taken to assess how the drug binds to proteins in the blood. Participants will undergo various safety checks and procedures. Participants will stay in the clinical unit until Day 5 for these assessments and will return on Day 10 for a final visit.

Recruiting

1 award

Phase 1

1 criteria

Mirdametinib

for Liver Disease

The purposes of this study are to determine: * The pharmacokinetics (the amount of study drug in your blood and how long it takes the body to get rid of it) of the study drug and its metabolites (substances produced as the body breaks down the study drug) in participants with moderate or severe liver function impairment compared to participants with normal liver function (also known as a healthy volunteer). Pharmacokinetics (or PK) is the study of how your body absorbs, breaks down, and removes a study drug. * How well the study drug is tolerated and any side effects that may occur in participants with moderate or severe liver function impairment compared to participants with normal liver function. This study is for research purposes only and is not intended to treat any medical condition.

Recruiting

1 award

Phase 1

2 criteria

ESK-001

for Liver Disease

This a phase 1, open label, single dose, parallel cohort study to determine the pharmacokinetics (PK) of study drug (ESK-001) in healthy volunteer participants, and participants with mild, moderate, and severe hepatic impairment.

Recruiting

1 award

Phase 1