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Nemours Children's Hospital
Claim this profileOrlando, Florida 32827
Global Leader in Cancer
Global Leader in Brain Tumor
Conducts research for Solid Tumors
Conducts research for Soft Tissue Sarcoma
Conducts research for Neuroblastoma
289 reported clinical trials
7 medical researchers
Summary
Nemours Children's Hospital is a medical facility located in Orlando, Florida. This center is recognized for care of Cancer, Brain Tumor, Solid Tumors, Soft Tissue Sarcoma, Neuroblastoma and other specialties. Nemours Children's Hospital is involved with conducting 289 clinical trials across 429 conditions. There are 7 research doctors associated with this hospital, such as Scott M. Bradfield, Ramamoorthy Nagasubramanian, Emi H. Caywood, and Mary Toth, MD.Area of expertise
1Cancer
Global LeaderStage IV
Stage I
Stage II
2Brain Tumor
Global LeaderStage IV
NTRK positive
Stage I
Top PIs
Scott M. BradfieldAlfred I duPont Hospital for Children8 years of reported clinical research
Expert in Brain Tumor
Expert in Cancer
45 reported clinical trials
81 drugs studied
Ramamoorthy NagasubramanianNemours Children's Clinic-Jacksonville4 years of reported clinical research
Studies Cancer
Studies Neuroblastoma
28 reported clinical trials
62 drugs studied
Emi H. CaywoodAlfred I duPont Hospital for Children6 years of reported clinical research
Studies Acute Lymphoblastic Leukemia
Studies Acute Leukemia
23 reported clinical trials
63 drugs studied
Mary Toth, MDNemours Children's Health2 years of reported clinical research
Studies Juvenile Arthritis
Studies Still's Disease
4 reported clinical trials
5 drugs studied
Clinical Trials running at Nemours Children's Hospital
Brain Tumor
Testicular cancer
Wilms Tumor
Neuroblastoma
Cancer
Acute Lymphoblastic Leukemia
Burkitt Lymphoma
Leukemia
Solid Tumors
Biphenotypic Leukemia
Selumetinib vs. Chemotherapy
for Brain Cancer
This trial is comparing a new drug, selumetinib, with standard chemotherapy to treat patients with a specific type of brain tumor. The patients do not have a certain genetic mutation and are not affected by a genetic disorder. Selumetinib works by blocking enzymes needed for tumor growth, while the standard drugs kill or stop tumor cells from dividing.
Recruiting2 awards Phase 3
Repotrectinib
for Solid Tumors in Young Patients
Phase 1 will evaluate the safety and tolerability at different dose levels of repotrectinib in pediatric and young adult subjects with advanced or metastatic malignancies harboring anaplastic lymphoma kinase (ALK), receptor tyrosine kinase encoded by the gene ROS1 (ROS1), or neurotrophic receptor kinase genes encoding TRK kinase family (NTRK1-3) alterations to estimate the Maximum Tolerated Dose (MTD) or Maximum Administered Dose (MAD) and select the Pediatric Recommended Phase 2 Dose (RP2D). Phase 2 will determine the anti-tumor activity of repotrectinib in pediatric and young adult subjects with advanced or metastatic malignancies harboring ROS1 or NTRK1-3 alterations.
Recruiting1 award Phase 1 & 214 criteria
Lower Radiotherapy Dose
for Brain Tumors
This phase II trial studies how well lower dose radiotherapy after chemotherapy (Carboplatin \& Etoposide) works in treating children with central nervous system (CNS) germinomas. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of tumor cells. Etoposide is in a class of medications known as podophyllotoxin derivatives. It blocks a certain enzyme needed for cell division and DNA repair and may kill cancer cells. Researchers want to see if lowering the dose of standard radiotherapy (RT) after chemotherapy can help get rid of CNS germinomas with fewer long-term side effects.
Recruiting1 award Phase 210 criteria
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Frequently asked questions
What kind of research happens at Nemours Children's Hospital?
Nemours Children's Hospital is a medical facility located in Orlando, Florida. This center is recognized for care of Cancer, Brain Tumor, Solid Tumors, Soft Tissue Sarcoma, Neuroblastoma and other specialties. Nemours Children's Hospital is involved with conducting 289 clinical trials across 429 conditions. There are 7 research doctors associated with this hospital, such as Scott M. Bradfield, Ramamoorthy Nagasubramanian, Emi H. Caywood, and Mary Toth, MD.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.