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Nationwide Children's Hospital
Claim this profileColumbus, Ohio 43205
Global Leader in Brain Tumor
Global Leader in Cancer
Conducts research for Cystic Fibrosis
Conducts research for Leukemia
Conducts research for Acute Lymphoblastic Leukemia
1069 reported clinical trials
67 medical researchers
Summary
Nationwide Children's Hospital is a medical facility located in Columbus, Ohio. This center is recognized for care of Brain Tumor, Cancer, Cystic Fibrosis, Leukemia, Acute Lymphoblastic Leukemia and other specialties. Nationwide Children's Hospital is involved with conducting 1,069 clinical trials across 1,318 conditions. There are 67 research doctors associated with this hospital, such as Mark Ranalli, Pablo Sanchez, MD, Maryam Fouladi, MD, and Bhuvana Setty, M.D..Area of expertise
1Brain Tumor
Global LeaderStage IV
NTRK positive
Stage I
2Cancer
Global LeaderStage IV
Stage I
Stage II
Top PIs
Mark RanalliNationwide Children's Hospital8 years of reported clinical research
Expert in Cancer
Expert in Neuroblastoma
71 reported clinical trials
125 drugs studied
Pablo Sanchez, MDResearch Institute at Nationwide Children's Hospital7 years of reported clinical research
Studies Neonatal Diseases
Studies Premature Birth
14 reported clinical trials
22 drugs studied
Maryam Fouladi, MDNationwide Children's Hospital7 years of reported clinical research
Expert in Brain Tumor
Studies Diffuse Intrinsic Pontine Glioma
14 reported clinical trials
21 drugs studied
Bhuvana Setty, M.D.Nationwide Children's Hospital4 years of reported clinical research
Studies Soft Tissue Sarcoma
Studies Ewing Sarcoma
10 reported clinical trials
20 drugs studied
Clinical Trials running at Nationwide Children's Hospital
Neuroblastoma
Brain Tumor
Testicular cancer
Cystic Fibrosis
Cardiovascular Disease
Cancer
Crohn's Disease
Ovarian Carcinoma
Ovarian Tumors
Testicular Carcinoma
Dinutuximab + Chemotherapy
for High-Risk Neuroblastoma
This phase III trial tests how well the addition of dinutuximab to Induction chemotherapy along with standard of care surgical resection of the primary tumor, radiation, stem cell transplantation, and immunotherapy works for treating children with newly diagnosed high-risk neuroblastoma. Dinutuximab is a monoclonal antibody that binds to a molecule called GD2, which is found on the surface of neuroblastoma cells, but is not present on many healthy or normal cells in the body. When dinutuximab binds to the neuroblastoma cells, it helps signal the immune system to kill the tumor cells. This helps the cells of the immune system kill the cancer cells, this is a type of immunotherapy. When chemotherapy and immunotherapy are given together, during the same treatment cycle, it is called chemoimmunotherapy. This clinical trial randomly assigns patients to receive either standard chemotherapy and surgery or chemoimmunotherapy (chemotherapy plus dinutuximab) and surgery during Induction therapy. Chemotherapy drugs administered during Induction include, cyclophosphamide, topotecan, cisplatin, etoposide, vincristine, and doxorubicin. These drugs work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing or by stopping them from spreading. Upon completion of 5 cycles of Induction therapy, a disease evaluation is completed to determine how well the treatment worked. If the tumor responds to therapy, patients receive a tandem transplantation with stem cell rescue. If the tumor has little improvement or worsens, patients receive chemoimmunotherapy on Extended Induction. During Extended Induction, dinutuximab is given with irinotecan, temozolomide. Patients with a good response to therapy move on to Consolidation therapy, when very high doses of chemotherapy are given at two separate points to kill any remaining cancer cells. Following, transplant, radiation therapy is given to the site where the cancer originated (primary site) and to any other areas that are still active at the end of Induction. The final stage of therapy is Post-Consolidation. During Post-Consolidation, dinutuximab is given with isotretinoin, with the goal of maintaining the response achieved with the previous therapy. Adding dinutuximab to Induction chemotherapy along with standard of care surgical resection of the primary tumor, radiation, stem cell transplantation, and immunotherapy may be better at treating children with newly diagnosed high-risk neuroblastoma.
Recruiting2 awards Phase 37 criteria
Lorlatinib + Standard Therapy
for Neuroblastoma
This phase III trial studies iobenguane I-131 or lorlatinib and standard therapy in treating younger patients with newly-diagnosed high-risk neuroblastoma or ganglioneuroblastoma. Radioactive drugs, such as iobenguane I-131, may carry radiation directly to tumor cells and not harm normal cells. Lorlatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving iobenguane I-131 or lorlatinib and standard therapy may work better compared to lorlatinib and standard therapy alone in treating younger patients with neuroblastoma or ganglioneuroblastoma.
Recruiting2 awards Phase 322 criteria
Biology Study
for Neuroblastoma
Medical scientists want to find better ways to treat neuroblastoma and to find ways to prevent the tumor from growing back. To do this, they need more information about the characteristics of neuroblastoma cells. Therefore, they want to study samples of neuroblastoma tissues and neuroblastoma and normal cells in the blood and bone marrow that may be related to the growth of neuroblastoma cells. Doctors and other medical scientists also want to find better ways to detect and measure neuroblastoma to improve the ability to follow the response of tumor cells to therapy.
Recruiting1 award N/A4 criteria
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Frequently asked questions
What kind of research happens at Nationwide Children's Hospital?
Nationwide Children's Hospital is a medical facility located in Columbus, Ohio. This center is recognized for care of Brain Tumor, Cancer, Cystic Fibrosis, Leukemia, Acute Lymphoblastic Leukemia and other specialties. Nationwide Children's Hospital is involved with conducting 1,069 clinical trials across 1,318 conditions. There are 67 research doctors associated with this hospital, such as Mark Ranalli, Pablo Sanchez, MD, Maryam Fouladi, MD, and Bhuvana Setty, M.D..
Where is Nationwide Children's Hospital located?
To reach Nationwide Children's Hospital, located at 700 Children's Drive, Columbus, OH 43205, take I-70 or I-670 to the 700 Children's Drive exit. Follow the blue path marked by colored flooring stripes and three-part directions to navigate within the hospital. For real-time driving directions, consider using Waze.
Who should I call to ask about financial aid or insurance network?
**Nationwide Children's Hospital Financial and Insurance Assistance**
- **Financial Assistance:** For aid, call (614) 466-1700 or visit the Children with Medical Handicaps (CMH) website. Programs include Nationwide Children's Hospital Financial Assistance, Hospital Care Assurance Program (HCAP), Ohio Healthy Start, Healthy Families, MiChild, Healthy Kids – Michigan Department of Health and Human Services, Children with Medical Handicaps (CMH), Ohio Medicaid for the Disabled and Aged, and Health Care Exchanges.
- **Insurance Matters:** For insurance inquiries, dial (888) 908-2498 or check their website for billing and insurance info, including financial assistance and health insurance details.
- **Billing or Insurance Questions:** Contact Patient Account Representatives at (614) 722-2055 or email Children'sPatientAccounts@NationwideChildrens.org for assistance with billing issues or insurance queries.
- **General Inquiries or Planned Giving:** Reach out to Nationwide Children's Hospital Foundation at (614) 722-2070 or 1-800-324-8680 for any general questions or information on making donations.
What insurance does Nationwide Children's Hospital accept?
Nationwide Children's Hospital is a "preferred provider" for various managed care plans, including Caresource Marketplace. Patients should confirm coverage and restrictions with their insurance provider before scheduling visits and procedures. It's important to ensure that your child's preferred providers are in-network, especially if choosing insurance through new health care exchanges, due to limited or no out-of-network benefits.
What awards or recognition has Nationwide Children's Hospital received?
Nationwide Children's Hospital, located in Columbus, Ohio, is renowned for its extensive clinical research, with over 1000 active projects aimed at advancing pediatric care through novel therapeutics and diagnostic tests. Since its founding in 1892, it has been at the forefront of pediatric research, including significant studies on rhinoviruses, microvolume blood testing, and pioneering the first human gene therapy trial for Duchenne muscular dystrophy. The hospital has been recognized with the James B. Recchie Design Award for its child and family-centered design and has earned accreditation from the Adult Congenital Heart Association for its exceptional service to adults with congenital heart disease.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.