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Nationwide Children's Hospital

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Columbus, Ohio 43205

Global Leader in Brain Tumor

Global Leader in Cancer

Conducts research for Cystic Fibrosis

Conducts research for Leukemia

Conducts research for Acute Lymphoblastic Leukemia

1069 reported clinical trials

67 medical researchers

Photo of Nationwide Children's Hospital in ColumbusPhoto of Nationwide Children's Hospital in ColumbusPhoto of Nationwide Children's Hospital in Columbus

Summary

Nationwide Children's Hospital is a medical facility located in Columbus, Ohio. This center is recognized for care of Brain Tumor, Cancer, Cystic Fibrosis, Leukemia, Acute Lymphoblastic Leukemia and other specialties. Nationwide Children's Hospital is involved with conducting 1,069 clinical trials across 1,330 conditions. There are 67 research doctors associated with this hospital, such as Mark Ranalli, Pablo Sanchez, MD, Maryam Fouladi, MD, and Bhuvana Setty, M.D..

Area of expertise

1

Brain Tumor

Global Leader

Nationwide Children's Hospital has run 94 trials for Brain Tumor. Some of their research focus areas include:

Stage IV
NTRK positive
Stage I
2

Cancer

Global Leader

Nationwide Children's Hospital has run 81 trials for Cancer. Some of their research focus areas include:

Stage IV
Stage I
Stage II

Top PIs

Clinical Trials running at Nationwide Children's Hospital

Testicular cancer

Acute Lymphoblastic Leukemia

Rett Syndrome

Neuroblastoma

Leukemia

Cancer

Myelodysplastic Syndrome

Cystic Fibrosis

Acute Myeloid Leukemia

Genetic Disorders

Image of trial facility.

Chemotherapy

for Cancer

This phase III trial studies how well active surveillance help doctors to monitor subjects with low risk germ cell tumors for recurrence after their tumor is removed. When the germ cell tumor has spread outside of the organ in which it developed, it is considered metastatic. Chemotherapy drugs, such as bleomycin, carboplatin, etoposide, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. The trial studies whether carboplatin or cisplatin is the preferred chemotherapy to use in treating metastatic standard risk germ cell tumors.

Recruiting

2 awards

Phase 3

26 criteria

Image of trial facility.

Chemotherapy + Radiation Therapy

for Brain Cancer

This phase II trial studies the best approach to combine chemotherapy and radiation therapy (RT) based on the patient's response to induction chemotherapy in patients with non-germinomatous germ cell tumors (NGGCT) that have not spread to other parts of the brain or body (localized). This study has 2 goals: 1) optimizing radiation for patients who respond well to induction chemotherapy to diminish spinal cord relapses, 2) utilizing higher dose chemotherapy followed by conventional RT in patients who did not respond to induction chemotherapy. Chemotherapy drugs, such as carboplatin, etoposide, ifosfamide, and thiotepa, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy x-rays or high-energy protons to kill tumor cells and shrink tumors. Studies have shown that patients with newly-diagnosed localized NGGCT, whose disease responds well to chemotherapy before receiving radiation therapy, are more likely to be free of the disease for a longer time than are patients for whom the chemotherapy does not efficiently eliminate or reduce the size of the tumor. The purpose of this study is to see how well the tumors respond to induction chemotherapy to decide what treatment to give next. Some patients will be given RT to the spine and a portion of the brain. Others will be given high dose chemotherapy and a stem cell transplant before RT to the whole brain and spine. Giving treatment based on the response to induction chemotherapy may lower the side effects of radiation in some patients and adjust the therapy to a more efficient one for other patients with localized NGGCT.

Recruiting

1 award

Phase 2

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