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Kaiser Permanente-Oakland

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Oakland, California 94611

Global Leader in Breast Cancer

Global Leader in Cancer

Conducts research for Lung Cancer

Conducts research for Brain Tumor

Conducts research for Lymphoma

450 reported clinical trials

12 medical researchers

Photo of Kaiser Permanente-Oakland in OaklandPhoto of Kaiser Permanente-Oakland in OaklandPhoto of Kaiser Permanente-Oakland in Oakland

Summary

Kaiser Permanente-Oakland is a medical facility located in Oakland, California. This center is recognized for care of Breast Cancer, Cancer, Lung Cancer, Brain Tumor, Lymphoma and other specialties. Kaiser Permanente-Oakland is involved with conducting 450 clinical trials across 608 conditions. There are 12 research doctors associated with this hospital, such as Aarati Rao, Laura A. Campbell, Jennifer M. Suga, and Tatjana Kolevska, MD.

Area of expertise

1

Breast Cancer

Global Leader

Kaiser Permanente-Oakland has run 68 trials for Breast Cancer. Some of their research focus areas include:

ER positive
HER2 negative
Stage II
2

Cancer

Global Leader

Kaiser Permanente-Oakland has run 65 trials for Cancer. Some of their research focus areas include:

Stage IV
Stage I
Stage II

Top PIs

Clinical Trials running at Kaiser Permanente-Oakland

Lung Cancer

Skin Cancer

Breast Cancer

Cancer

Prostate Cancer

Breast cancer

Ovarian Cancer

Testicular cancer

Melanoma

Brain Tumor

Image of trial facility.

Chemotherapy + Immunotherapy vs. Immunotherapy

for Advanced Lung Cancer

This phase III trial compares the effect of adding chemotherapy to immunotherapy (pembrolizumab) versus immunotherapy alone in treating patients with stage IIIB-IV lung cancer. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving pembrolizumab and chemotherapy may help stabilize lung cancer.

Recruiting

2 awards

Phase 3

Image of trial facility.

Treatment Timing

for Non-Small Cell Lung Cancer

This phase III trial compares standard therapy given after surgery (adjuvant) to standard therapy given before and after surgery (perioperative) in treating patients with stage II-IIIB non-small cell lung cancer (NSCLC) that can be removed by surgery (resectable). The usual approach for patients with resectable NSCLC is chemotherapy and/or immunotherapy before surgery, after surgery, or both before and after surgery. This study is being done to find out which approach is better at treating patients with lung cancer. Treatment will be administered according to the current standard of care at the time of enrollment. Chemotherapy options may include cisplatin, carboplatin, pemetrexed, gemcitabine, docetaxel, and vinorelbine at standard doses according to the treating physician. Cisplatin is in a class of medications known as platinum-containing compounds. It works by killing, stopping or slowing the growth of tumor cells. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of tumor cells. Pemetrexed is in a class of medications called antifolate antineoplastic agents. It works by stopping cells from using folic acid to make deoxyribonucleic acid (DNA) and may kill tumor cells. Gemcitabine is a chemotherapy drug that blocks the cells from making DNA and may kill tumor cells. Docetaxel is in a class of medications called taxanes. It stops tumor cells from growing and dividing and may kill them. Other chemotherapy drugs, such as vinorelbine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading . Immunotherapy with monoclonal antibodies, such as nivolumab, pembrolizumab, and atezolizumab, may help the body's immune system attack the tumor, and may interfere with the ability of tumor cells to grow and spread. Starting treatment with chemotherapy and immunotherapy prior to surgery and continuing treatment after surgery may be a more effective treatment option than adjuvant therapy alone in patients with stage II-IIIB resectable NSCLC.

Recruiting

2 awards

Phase 3

4 criteria

Image of trial facility.

Sacituzumab Tirumotecan vs Standard Therapy

for Lung Cancer

The purpose of this study is to evaluate sacituzumab tirumotecan versus pemetrexed in combination with carboplatin for the treatment of epidermal growth factor receptor (EGFR)-mutated advanced non-squamous non-small cell lung cancer (NSCLC). Participants in this study have NSCLC that has continued to progress on prior treatment with EGFR tyrosine kinase inhibitors (TKIs). The primary hypotheses of this study are that sacituzumab tirumotecan is better than platinum-based doublet chemotherapy (pemetrexed and carboplatin) in regard to progression-free survival (PFS) and overall survival (OS).

Recruiting

2 awards

Phase 3

2 criteria

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