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Conditioned Stimulus - (CS-): Flavored beverage solution with sweetness-matched sucralose for Obesity

N/A
Waitlist Available
Research Sponsored by Virginia Polytechnic Institute and State University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 30-minute measurement
Awards & highlights

Study Summary

This trial is testing whether differences in reinforcement learning/flavor-nutrient conditioning of carbohydrate can be measured across the body mass index range, and whether there is a relationship between metabolic flexibility and calorie-predictive reward.

Eligible Conditions
  • Overweight and Obesity

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~30-minute measurement
This trial's timeline: 3 weeks for screening, Varies for treatment, and 30-minute measurement for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in preference- liking
Secondary outcome measures
Blood glucose response to beverages
Blood insulin response to beverages
Oxygen saturation measurement
+5 more

Trial Design

4Treatment groups
Experimental Treatment
Group I: Conditioned Stimulus- (CS-) and High Fat Test Meal FirstExperimental Treatment4 Interventions
Participants will undergo exposure sessions with flavored beverage solutions containing sucralose first. They will also undergo the high fat meal test session inside the metabolic chamber first. Then, they will undergo exposure sessions with flavored beverages containing sucrose and the high carbohydrate test meal session.
Group II: Conditioned Stimulus- (CS-) and High Carbohydrate Test Meal FirstExperimental Treatment4 Interventions
Participants will undergo exposure sessions with flavored beverage solutions containing sucralose first. They will also undergo the high carbohydrate meal test session inside the metabolic chamber first. Then, they will undergo exposure sessions with flavored beverages containing sucrose and the high fat test meal session.
Group III: Conditioned Stimulus+ (CS+) and High Fat Test Meal FirstExperimental Treatment4 Interventions
Participants will undergo exposure sessions with flavored beverage solutions containing sucrose first. They will also undergo the high fat meal test session inside the metabolic chamber first. Then, they will undergo exposure sessions with flavored beverages containing sucralose and the high carbohydrate test meal session.
Group IV: Conditioned Stimulus+ (CS+) and High Carbohydrate Test Meal FirstExperimental Treatment4 Interventions
Participants will undergo exposure sessions with flavored beverage solutions containing sucrose first. They will also undergo the high carbohydrate meal test session inside the metabolic chamber first. Then, they will undergo exposure sessions with flavored beverages containing sucralose and the high fat test meal session.

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Who is running the clinical trial?

Virginia Polytechnic Institute and State UniversityLead Sponsor
144 Previous Clinical Trials
27,810 Total Patients Enrolled
9 Trials studying Obesity
4,215 Patients Enrolled for Obesity
~6 spots leftby May 2025
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