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Exercise for Lung Cancer
N/A
Waitlist Available
Led By Lee Jones, PhD
Research Sponsored by Memorial Sloan Kettering Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Age 21 - 80 years
Diagnosed with histologically confirmed lung cancer, regardless of disease stage and receiving any prior line of any therapy in the context of metastatic disease
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 17 weeks
Awards & highlights
Study Summary
This trial will look at the effects of different types of exercise on lung cancer patients. The 16 week training intervention will include aerobic, resistance, aerobic & resistance, or a control group. Pre and Post testing will include stress tests, echos, blood, and urine samples.
Who is the study for?
This trial is for lung cancer patients aged 21-80 with exercise intolerance, a life expectancy of at least 4 months, and who do less than 150 minutes of moderate to strenuous exercise weekly. They must have completed primary therapy within the last ten years and be willing to follow the study program. Excluded are those with severe oxygen deficiency at rest or other active cancers treated in the past three years.Check my eligibility
What is being tested?
The study examines how different types of exercise affect lung cancer patients over a 16-week period. Participants will engage in aerobic, resistance training, combined exercises or stretching as control. Their fitness levels will be measured before and after via stress tests, echos, blood and urine samples.See study design
What are the potential side effects?
While not drug-related, side effects from participating in this trial may include typical risks associated with physical activity such as muscle soreness, fatigue or injury. The intensity of these side effects can vary based on individual health status.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am between 21 and 80 years old.
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I have lung cancer at any stage and have received treatment for it when it was metastatic.
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I weigh less than 205 kilograms.
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I can perform well on a cardio fitness test.
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It has been over 3 months since my last surgery.
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I am fully active and can carry on all my pre-disease activities without restriction.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 17 weeks
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~17 weeks
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
changes in VO2peak (on exercise capacity)
Trial Design
4Treatment groups
Experimental Treatment
Active Control
Group I: Resistance TrainingExperimental Treatment1 Intervention
A customized and supervised resistance exercise training program that will last 4 months (16 weeks). Resistance training will be performed on stationary weight machines, modification in equipment may be made by Exercise Physiologist. Patients will be progressively trained to perform two to three sets of 75-85% of maximal strength The participant will be trained to perform different resistance exercise, alternating between lower and upper body muscle groups. The exercise program will consist of three supervised sessions per week. Each session will last approximately 30-60 minutes.
Group II: Combined Aerobic and Resistance TrainingExperimental Treatment1 Intervention
A customized and supervised endurance exercise training program that will last 4 months (16 weeks). The regimen will be tailored to the individual fitness level, and will be a combination of Arm A and Arm B, described above. At each session, the participant will complete aerobic training on a stationary bicycle and also resistance training using stationary weight machines. The exercise program will consist of three supervised sessions per week. Each session will last approximately 30-90 minutes.
Group III: Aerobic TrainingExperimental Treatment1 Intervention
A customized and supervised endurance exercise training program that will last 4 months (16 weeks). The regimen will be tailored to the individual fitness level. The exercise program will consist of three supervised sessions per week. During each session, the participant will cycle on a stationary bicycle at moderate intensity for approximately 30-60 minutes.
Group IV: Progressive Stretching Group (Attention-Control)Active Control1 Intervention
A customized and supervised progressive stretching program that will last 4 months (16 weeks). The progressive stretching program will consist of a series of stretching exercises alternating between lower and upper body muscle groups/joints. This program will consist of three exercise sessions a week. Each session will last approximately 30-60 minutes.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Exercise Training
2011
Completed Phase 3
~1440
Find a Location
Who is running the clinical trial?
Memorial Sloan Kettering Cancer CenterLead Sponsor
1,937 Previous Clinical Trials
588,303 Total Patients Enrolled
Duke UniversityOTHER
2,367 Previous Clinical Trials
3,424,830 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,687 Previous Clinical Trials
40,930,354 Total Patients Enrolled
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Eligibility Criteria:
This trial includes the following eligibility criteria:- You are expected to live for at least 4 more months.You have trouble exercising, and your ability to use oxygen during physical activity is lower than expected for someone your age and gender.I am between 21 and 80 years old.I do not have another cancer being treated now, nor have I been treated for another cancer in the past 3 years, except for non-melanoma skin cancer.I have lung cancer at any stage and have received treatment for it when it was metastatic.It has been less than 10 years since I finished my main cancer treatment.I weigh less than 205 kilograms.You need to be able to do a strength test without feeling a lot of pain or discomfort.I can perform well on a cardio fitness test.I am mentally capable of following study procedures.You do not exercise for at least 150 minutes per week at a moderate or strenuous level.Your oxygen levels drop to 85% or lower when you're resting.It has been over 3 months since my last surgery.I am fully active and can carry on all my pre-disease activities without restriction.
Research Study Groups:
This trial has the following groups:- Group 1: Progressive Stretching Group (Attention-Control)
- Group 2: Combined Aerobic and Resistance Training
- Group 3: Aerobic Training
- Group 4: Resistance Training
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is enrollment in this trial still open?
"Per clinicaltrials.gov, this particular trial has closed to enrollment after the most recent update on October 18th 2022. Initially posted in 2015, it is no longer seeking applicants; however, 1631 other studies are actively recruiting participants at present."
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