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Diuretic

KMgCit + Chlorthalidone for High Blood Pressure

N/A
Waitlist Available
Led By Wanpen Vongpatanasin, MD
Research Sponsored by University of Texas Southwestern Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
• Treated or untreated stage I hypertension
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up week 4 to week 16
Awards & highlights

Study Summary

This trial will test if a potassium magnesium citrate supplement can help offset some of the adverse metabolic effects of chlorthalidone, beyond just correcting for hypokalemia.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~week 4 to week 16
This trial's timeline: 3 weeks for screening, Varies for treatment, and week 4 to week 16 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Fasting Plasma Glucose From Week 4 to Week 16
Secondary outcome measures
Chang in Hepatic Fat Measured at Baseline and Week 16
Change in FGF23 From Week 4 to Week 16
Change in Muscle Magnesium Content Measured at Baseline and Week 16

Trial Design

2Treatment groups
Active Control
Group I: KMgCit + ChlorthalidoneActive Control2 Interventions
After a run-in period of 2-3 weeks on Chlorthalidone, patients will be randomized to the addition of KMgCit for 4 months.
Group II: KCl + ChlorthalidoneActive Control2 Interventions
After a run-in period of 2-3 weeks on Chlorthalidone, patients will be randomized to the addition of KCl for 4 months.

Find a Location

Who is running the clinical trial?

University of Texas Southwestern Medical CenterLead Sponsor
1,055 Previous Clinical Trials
1,054,808 Total Patients Enrolled
Wanpen Vongpatanasin, MDPrincipal Investigator - UT Southwestern Medical Center
Children's Medical Center of Dallas, The University of Texas Southwestern Medical Center At Dallas, UT Southwestern Medical Center-Zale Lipshy Campus
Chulalongkorn University (Medical School)
University Tx Southwestern Medical Sch (Residency)
11 Previous Clinical Trials
744 Total Patients Enrolled
~6 spots leftby Jun 2025
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