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MRI for Renal Fibrosis Detection

N/A
Recruiting
Led By Lilach O Lerman, MD, PhD
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients are competent and able to provide written informed consent
Patients with hypertension (BP>140/90 mmHg) and/or requirement for two or more antihypertensive medications for more than 4 weeks
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline
Awards & highlights

Study Summary

This trial looks at whether an MRI technique can accurately predict kidney function.

Who is the study for?
This trial is for adults aged 40-80 with high blood pressure needing multiple medications and normal kidney function (creatinine under specific levels). They must not have severe allergies to contrast agents, metal implants incompatible with MRI, claustrophobia, or conditions preventing protocol compliance. Excluded are those with recent serious medical events, uncontrolled hypertension, diabetes on medication, certain infections or drug requirements, heart issues, recent thrombosis, kidney transplant recipients or stones.Check my eligibility
What is being tested?
The study tests if a special MRI technique called qMT can detect fibrosis in kidneys affected by narrowed arteries and predict recovery. It checks the method's feasibility and reliability in patients who meet specific health criteria.See study design
What are the potential side effects?
Since this trial involves an imaging procedure rather than a drug intervention, side effects may include discomfort from lying still during the scan or reactions to any contrast material used if applicable.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am mentally capable of understanding and signing the consent form.
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I have high blood pressure or take two or more blood pressure medications.
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I am between 40 and 80 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Fibrosis assessed by qMT-MRI in the stenotic kidney and contralateral kidneys
Secondary outcome measures
Fibrosis assessed by qMT-MRI compared to stenotic kidney function
Fibrosis assessed by qMT-MRI compared to stenotic kidney injury markers

Trial Design

1Treatment groups
Experimental Treatment
Group I: Early identification of fibrosis.Experimental Treatment1 Intervention
A pilot study to test the ability of qMT to quantify fibrosis in the post-stenotic human kidney, in comparison to innovative biomarkers of renal dysfunction and tissue damage. We will pursue the Specific Aim that qMT in stenotic human kidneys is feasible and reproducible.

Find a Location

Who is running the clinical trial?

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NIH
2,369 Previous Clinical Trials
4,316,570 Total Patients Enrolled
Mayo ClinicLead Sponsor
3,233 Previous Clinical Trials
3,771,799 Total Patients Enrolled
Lilach O Lerman, MD, PhDPrincipal Investigator - Mayo Clinic
Mayo Clinic

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who qualifies as an appropriate participant for this investigation?

"Eligible participants for this hypertension clinical trial must be between the ages of 40 and 80, with a maximum capacity of 27 enrollees."

Answered by AI

Are there still opportunities for individuals to participate in this experiment?

"Clinicaltrials.gov reveals that this medical study, established on October 1st 2020, is actively looking for volunteers to partake in the trial. The details of the research were last altered on October 27th 2022."

Answered by AI

How many participants are actively engaged in the research?

"Correct. According to clinicaltrials.gov, this experiment is still seeking participants as it was initially posted on October 1st 2020 and the most recent edit took place on October 27th 2022. A total of 27 individuals from a single location are needed for recruitment."

Answered by AI

Are persons who have not yet reached the age of octogenarianism accepted into this medical trial?

"Patients between the ages of 40 to 80 are eligible for this trial. Alternatively, there are 128 clinical trials available for minors and 1016 studies open to seniors."

Answered by AI

Who else is applying?

What site did they apply to?
Mayo Clinic in Rochester
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
A Study to Evaluate Renal Fibrosis Using MRI Techniques
Lilach O Lerman 2020. "A Study to Evaluate Renal Fibrosis Using MRI Techniques". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04508049.
All > Fibrosis > Hypertension
~6 spots leftby Jun 2025
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