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Skin Conductance Metrics for Fear of Pain

N/A
Recruiting
Led By Fred A Lenz, MD PhD
Research Sponsored by Johns Hopkins University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Man or woman between 18 and 80 years of age
Possess ability to understand study procedures and comply with them for the entire length of the study
Timeline
Screening 3 weeks
Treatment Varies
Follow Up the whole duration of the study up to 5 years
Awards & highlights

Study Summary

This trial will study how people with job-related pain form expectations of pain and how this affects their disability. Results may lead to better diagnosis/management of PTSD & anxiety disorders.

Who is the study for?
This trial is for English-speaking adults aged 18-80 who are undergoing seizure monitoring at Hopkins Hospital and can follow the study's procedures. Women of childbearing age must use birth control. It excludes those with unstable neurological or psychiatric conditions, significant neuropsychological test abnormalities, abnormal MRI (except specific variants), pregnant women, non-English speakers, and individuals with certain types of seizures.Check my eligibility
What is being tested?
The study aims to develop new methods to measure the expectation of pain and attention related to threats using skin conductance as a metric for anxiety. These methods could help diagnose and manage PTSD and anxiety disorders by understanding how environments associated with injury influence fear of pain.See study design
What are the potential side effects?
Since this trial involves measurement techniques rather than medication or invasive treatments, traditional side effects are not applicable. However, participants may experience discomfort or stress related to the anticipation of pain during testing.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 80 years old.
Select...
I understand and can follow the study's procedures.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~the whole duration of the study up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and the whole duration of the study up to 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Anxiety as assessed by the Spielberg Anxiety Inventory
Conditioned fear as assessed by skin conductance
Experimental Pain as assessed by a pain rating scale
Secondary outcome measures
Parts of the brain outside the predicted models.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Eye position and tense arousal over time a metrics for sustained attention in conditioned fear.Experimental Treatment1 Intervention
After conditioning the conditioned stimulus induces autonomic metrics like skin conductance and cognitive ratings like expectancy of the unconditioned stimulus after conditioning. Activity across blocks in the conditioning stage demonstrates that the skin conductance can produce a progressive decrease in skin conductance over the conditioning stage of our fear conditioning protocol. The decline is not apparently related to habituation or changes in the skin conducting electrodes or recording system. It does correspond to the decrease in performance of a visual fixation task which is part of the fear conditioning during the conditioning stage; and to an increase in the unpleasant psychologic activation termed tense arousal over the same stage. If both these changes are found he then we may conclude that sustained task related attention is produced during fear conditioning

Find a Location

Who is running the clinical trial?

University of MarylandOTHER
161 Previous Clinical Trials
302,139 Total Patients Enrolled
Johns Hopkins UniversityLead Sponsor
2,282 Previous Clinical Trials
14,842,064 Total Patients Enrolled
Ohio State UniversityOTHER
842 Previous Clinical Trials
509,653 Total Patients Enrolled

Media Library

Conditioned Fear Clinical Trial Eligibility Overview. Trial Name: NCT03739645 — N/A
Fear of Pain Research Study Groups: Eye position and tense arousal over time a metrics for sustained attention in conditioned fear.
Fear of Pain Clinical Trial 2023: Conditioned Fear Highlights & Side Effects. Trial Name: NCT03739645 — N/A
Conditioned Fear 2023 Treatment Timeline for Medical Study. Trial Name: NCT03739645 — N/A
~75 spots leftby Jun 2028
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