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Hormone Therapy

Toviaz and Premarin Vaginal Cream for Overactive Bladder

Phase 4
Waitlist Available
Led By Eric Hurtado, MD
Research Sponsored by The Cleveland Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year
Awards & highlights

Study Summary

The use of vaginal estrogen cream in conjunction with Toviaz will be more effective than the use of Toviaz alone for the treatment of overactive bladder.

Eligible Conditions
  • Overactive Bladder

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Urinary frequency as measured by a 3 day voiding diary
Secondary outcome measures
Overactive Bladder

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Toviaz and Premarin Vaginal CreamExperimental Treatment2 Interventions
Toviaz 4 mg PO q day and premarin cream 1 g per vagina 2 times a week.
Group II: Toviaz , Placebo Premarin Vaginal CreamPlacebo Group2 Interventions
Toviaz 4 mg PO q day and placebo cream 1 g per vagina 2 times a week.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Fesoterodine
FDA approved
Conjugated estrogens
FDA approved

Find a Location

Who is running the clinical trial?

The Cleveland ClinicLead Sponsor
1,033 Previous Clinical Trials
1,365,294 Total Patients Enrolled
PfizerIndustry Sponsor
4,578 Previous Clinical Trials
10,923,712 Total Patients Enrolled
Alexandriah Alas, MDStudy DirectorCleveland Clinic Florida
1 Previous Clinical Trials
176 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Premarin Versus Toviaz for Treatment of Overactive Bladder
G. Willy Davila 2012. "Premarin Versus Toviaz for Treatment of Overactive Bladder". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01613170.
All > Overactive Bladder
~7 spots leftby May 2025
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