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SPG Block for Headache

Phase 4
Waitlist Available
Led By Tony Zitek, MD
Research Sponsored by Kendall Healthcare Group, Ltd.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Any patient at least 18 years old who presented to the ED with a suspected primary headache.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 24-72 hours
Awards & highlights

Study Summary

This trial will compare a nerve block to standard headache medication for people who come to the ER for a headache.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~24-72 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 24-72 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Percentage of Patients with Substantial Pain Reduction at 15 minutes
Secondary outcome measures
Change in Mean Pain Score at 15 minutes
Change in Mean Pain Score at 30 minutes
Headache 24-72 hours later
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: SPG BlockExperimental Treatment1 Intervention
Sphenopalatine ganglion block using cotton-tipped applicators soaked in 1% lidocaine will be performed.
Group II: Standard TreatmentActive Control1 Intervention
Intravenous prochlorperazine 10 mg plus diphenhydramine 50 mg.

Find a Location

Who is running the clinical trial?

Kendall Healthcare Group, Ltd.Lead Sponsor
6 Previous Clinical Trials
1,280 Total Patients Enrolled
Nova Southeastern UniversityOTHER
89 Previous Clinical Trials
11,557 Total Patients Enrolled
Tony Zitek, MDPrincipal InvestigatorKendall Healthcare Group, Ltd.
5 Previous Clinical Trials
496 Total Patients Enrolled
1 Trials studying Headache
58 Patients Enrolled for Headache

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
Headache: The Journal of Head and Face PainJournal
Intranasal Lidocaine for Migraine: A Randomized Trial and Open-label Follow-up
Maizels, Morris, and Ann M. Geiger. 1999. “Intranasal Lidocaine for Migraine: A Randomized Trial and Open-label Follow-up”. Headache: The Journal of Head and Face Pain. Wiley. doi:10.1046/j.1526-4610.1999.3908543.x.
JAMA: The Journal of the American Medical AssociationJournal
Intranasal Lidocaine for Treatment of Migraine
Diamond, M. L.. 1996. “Intranasal Lidocaine for Treatment of Migraine”. JAMA: The Journal of the American Medical Association. American Medical Association (AMA). doi:10.1001/jama.276.19.1553c.
clinicaltrials.govStudy
SPG Blocks for Headaches
2020. "SPG Blocks for Headaches". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04255420.
All > Headache
~16 spots leftby Apr 2025
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