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Metformin for Prostate Cancer (MAST Trial)
MAST Trial Summary
This trial will test whether metformin can improve outcomes for men with low-risk prostate cancer.
MAST Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowMAST Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2015 Phase 4 trial • 156 Patients • NCT02002221MAST Trial Design
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Who is running the clinical trial?
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- You have used drugs or alcohol excessively in the past year, as defined in the DSM-IV.I can swallow and keep down pills.I have received treatment for prostate cancer, including radiotherapy, chemotherapy, hormonal therapy, oral glucocorticoids, or GnRH analogues.I had prostate surgery less than 3 months ago.I have had cancer before, but it was either skin cancer, stage I melanoma, bladder cancer, or another type that was treated over 5 years ago with no current signs of disease.I am a man aged between 18 and 80.I chose to monitor my low-risk prostate cancer without immediate treatment for less than a year.My prostate cancer has a Gleason score of 6 or less, with no pattern 4 or above.I have not participated in any drug trials within the last 30 days.I am not currently taking diabetes medications like metformin, sulfonylureas, thiazolidinediones, or insulin.You have a medical or mental health condition that could affect the results of the study or put you at extra risk.My cancer is in an early stage, but it's growing.I haven't had a heart attack, stroke, or serious heart issues in the last 6 months.
- Group 1: Placebo
- Group 2: Metformin
- Pivotal Trial - The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
- Approved for 20 Other Conditions - This treatment demonstrated efficacy for 20 other conditions.
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
How can I become a test subject for this research?
"The prerequisites for this clinical trial are that the patient must have prostate cancer and be between 18-79 years old. This research is looking for around 408 individuals in total."
Is Metformin a common medication in clinical trials?
"There are a total of 180 clinical trials underway that are investigating the use of metformin. Of those, 46 are in Phase 3. Although many of the studies for metformin are based in Rockville, Maryland, there are a total of 1677 locations running studies for this treatment."
Are subjects being actively sought for this research project?
"That is correct, the trial is currently ongoing. As stated on clinicaltrials.gov, the trial was first posted on October 1st, 2013 and was last edited on April 16th, 2021. The trial is looking for 408 participants across 12 different sites."
Does this research project restrict participants to a certain age group?
"According to the eligibility requirements, patients enrolling in this trial must be between 18 and 79 years old. However, there are 99 other trials for people under 18 and 1481 for patients over 65."
How many research facilities are participating in this trial?
"In addition to MUHC - Montreal General Hospital in Montreal, Quebec, Sunnybrook Research Institute in Toronto, Nova Scotia, and Centre de Recherche du CHUS in Sherbrooke, Manitoba, this study is also taking place at 12 other sites."
Could you please touch on any possible dangers of Metformin?
"There is both pre-existing clinical data supporting Metformin's safety as well as multiple rounds of data from this Phase 3 trial, so it received a score of 3."
What are the most popular off-label uses for Metformin?
"Metformin is a medication that is regularly used to treat exercise, but it can also be prescribed for type 1 diabetes mellitus, diabetic ketoacidosis, and polycystic ovary syndrome."
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